Complete Blood Count (CBC): What This Test Is, Why It Is Done, and What Your Results Mean
This test measures the level of androstenedione, a hormone that serves as a building block for testosterone and estrogen, in your saliva.
{"Androstenedione is a hormone produced by the adrenal glands, ovaries, and testes","This saliva test helps doctors evaluate hormonal imbalances affecting puberty, fertility, or adrenal function","The test is simple, non-invasive, and can be done at home or in a clinic","Results help diagnose conditions like PCOS, adrenal disorders, or early/delayed puberty"}
Key facts at a glance
- LOINC
- 72489-8
- Short code
- ANDR-S
- Synonyms
- Androst Sal-sCnc
- Category
- chemistry
- Sample
- serum
- Container
- Saliva collection device (Salivette or specialized collection tube)
- Units
- N/A
- Ref low
- 0.3
- Ref high
- 3.1
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- ≥ 1 years
- Method
- Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) or Enzyme-Linked Immunosorbent Assay (ELISA)
- CPT
- 82157
- SNOMED
- 271426005
- Specimen volume
- 1-2 mL of saliva
- Stability
- Stable at room temperature for up to 7 days; refrigerated (2-8°C) for up to 14 days; frozen (-20°C or below) for up to 6 months. Avoid repeated freeze-thaw cycles.
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 72–168 hours
- Order
- routine
A complete blood count, or CBC, is a common blood test that measures the different cells in your blood, including red blood cells, white blood cells, and platelets. It gives your care team a broad picture of your overall health and how well your blood is doing its job.
The androstenedione test measures the amount of androstenedione hormone in your saliva. Androstenedione is produced by the adrenal glands (small glands on top of your kidneys), as well as the ovaries in women and testes in men. It acts as a precursor, meaning your body converts it into other important hormones like testosterone and estrogen.
This test is done to check your general health, look for conditions such as anemia, infection, or blood clotting problems, and to monitor an existing condition or how treatments like chemotherapy and certain medicines are affecting your blood cells.
Your doctor may order this test to help diagnose or monitor conditions related to hormonal imbalances, including: adrenal gland disorders (such as adrenal hyperplasia or tumors), polycystic ovary syndrome (PCOS), early or delayed puberty, excessive hair growth (hirsutism) in women, fertility problems, and certain cancers affecting hormone-producing tissues.
A healthcare professional will clean a small spot on your arm, wrap a band around your upper arm, and draw a small sample of blood from a vein using a thin needle. The sample is then sent to a laboratory for analysis, and the whole process usually takes only a few minutes.
For a saliva test, you will typically collect a sample of saliva in a small container or tube. This is usually done in the morning when hormone levels are most stable. You may be asked to avoid eating, drinking, or brushing your teeth before the test. The sample is then sent to a laboratory for analysis. Note: The test information indicates 'serum' as sample type, but the test name specifically refers to saliva. Please follow your healthcare provider's instructions regarding the correct sample type for your specific test.
Results within the normal ranges usually suggest that your blood cells are at healthy levels. Abnormal values may point to conditions such as anemia, infection, inflammation, or clotting problems, but your provider will interpret them together with your symptoms and medical history before making a diagnosis.
Normal androstenedione levels vary based on age, sex, and menstrual cycle phase (for women). High levels may indicate conditions such as PCOS, adrenal hyperplasia, adrenal tumors, or congenital adrenal hyperplasia. Low levels may suggest adrenal insufficiency or other adrenal disorders. Your doctor will interpret your results in the context of your symptoms, medical history, and other test results.
Reference range
Reference ranges vary by age, sex, and laboratory methodology. Typical adult ranges: Males 0.3-3.1 nmol/L; Females (premenopausal) 0.2-3.0 nmol/L; Females (postmenopausal) 0.2-1.8 nmol/L. Pediatric and adolescent ranges differ significantly.N/A
No special preparation required. Saliva collection should be performed according to kit instructions, typically avoiding eating, drinking, brushing teeth, or using oral hygiene products for at least 30 minutes prior to collection. For hormonal assessment, samples are often collected in the morning.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Androstenedione testing is clinically valuable for diagnosing and managing hormonal disorders. In women with PCOS, androstenedione levels are often elevated, helping confirm the diagnosis. For children with early or delayed puberty, this test helps determine if adrenal hormones are responsible. In adrenal disorders like congenital adrenal hyperplasia, monitoring androstenedione levels helps guide treatment. The test is also useful in evaluating adrenal tumors and in assessing hormonal causes of infertility or excessive hair growth.
Frequently asked questions
Do I need to prepare for the saliva test?
Is the saliva test painful?
How long does it take to get results?
Can I do the saliva test at home?
What factors can affect androstenedione levels?
Sources
- 1MedlinePlus - HormonesSource
- 2
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy