Complete Blood Count (CBC)
This test measures the level of androstenedione, a hormone that serves as a building block for testosterone and estrogen, in your blood.
{"Androstenedione is a hormone produced by the adrenal glands, ovaries, and testes","This test helps evaluate conditions related to excess or deficient androgen production","It is commonly used to investigate causes of abnormal hair growth, menstrual irregularities, or early puberty","The test requires a simple blood draw from a vein","Results are interpreted along with other hormone tests and clinical symptoms"}
Key facts at a glance
- LOINC
- 14603-5
- Short code
- ANDRO
- Synonyms
- Androst SerPl-sCnc
- Category
- chemistry
- Sample
- serum
- Container
- Red top (serum) or SST (Serum Separator Tube)
- Units
- N/A
- Ref low
- 0.3
- Ref high
- 3.5
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- ≥ 18 years
- Method
- Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) or Immunoassay
- CPT
- 82157
- SNOMED
- 41582007
- Specimen volume
- 1.0 mL serum or plasma
- Stability
- Room temperature: 8 hours; Refrigerated (2-8°C): 7 days; Frozen (-20°C): 30 days
- Hemolysis max
- 50
- Lipemia max
- 100
- Icterus max
- 20
- TAT
- 24–72 hours
- Order
- routine
What is this test? A complete blood count, or CBC, is a common blood test that measures the different cells in your blood, including red blood cells, white blood cells, platelets, hemoglobin, and hematocrit. It gives your healthcare team a broad picture of your overall health.
The androstenedione test measures the amount of androstenedione in your blood serum or plasma. Androstenedione is an androgen (male hormone) produced primarily by the adrenal glands in both men and women, and also by the ovaries in women and testes in men. It serves as a precursor hormone, meaning your body can convert it into other hormones like testosterone and estrogen.
Why is this test ordered? Your doctor may order a CBC as part of a routine health exam to screen for conditions such as anemia, infection, or blood disorders, to help evaluate symptoms like fatigue, weakness, fever, bruising, or unusual bleeding, and to monitor an existing condition or how a treatment is working.
Your healthcare provider may order an androstenedione test if you have symptoms suggesting a hormone imbalance. In women, this may include excess hair growth (hirsutism), acne, deepening voice, or menstrual irregularities. In men or children, it may be ordered for signs of early puberty or unusual muscle development. The test is also used to evaluate adrenal gland function and to help diagnose conditions like congenital adrenal hyperplasia, polycystic ovary syndrome (PCOS), or adrenal tumors.
How is the test performed? A healthcare professional will draw a small sample of blood from a vein in your arm, usually on the inside of the elbow, using a fine needle. The procedure takes only a few minutes, and you may feel a brief sting or pinch. No special preparation is usually required, and the sample is sent to a laboratory for analysis.
A healthcare professional will draw a small blood sample from a vein in your arm using a needle. The blood is collected into a tube and sent to a laboratory for analysis. You do not need to fast before this test, but your doctor may ask you to stop certain medications that could affect the results. It is important to inform your healthcare provider about all medications, supplements, or herbal products you are taking.
Understanding your results: Your report will show a measured value for each blood component next to a reference range, which is the range considered typical for healthy adults. Values that fall above or below these ranges may suggest conditions such as infection, anemia, dehydration, or clotting problems, but a single abnormal value does not confirm a diagnosis. Always review your results with your healthcare provider, who can interpret them alongside your symptoms, medical history, and other findings.
Normal androstenedione levels vary based on age, sex, and the laboratory that performs the test. Your results will be compared to a reference range specific to your age, sex, and sometimes menstrual cycle phase (for women). Elevated levels may indicate conditions such as PCOS, adrenal hyperplasia, adrenal tumors, or androgen-producing tumors. Low levels may be seen in adrenal insufficiency or certain genetic conditions. Your healthcare provider will interpret your results in the context of your symptoms and other test findings.
Reference range
Adult females: 0.3-3.5 nmol/L; Adult males: 0.5-2.5 nmol/L; Values vary by age, sex, and assay method. Reference ranges should be established by each laboratory.N/A
No special patient preparation required. However, sample collection timing is important as androstenedione has diurnal variation.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
The androstenedione test is clinically significant for diagnosing and monitoring disorders of androgen excess or deficiency. Elevated androstenedione levels are commonly found in women with polycystic ovary syndrome (PCOS), where it contributes to symptoms like hirsutism and acne. In congenital adrenal hyperplasia, enzyme deficiencies lead to accumulation of androstenedione. Adrenal tumors may cause excessive androgen production. The test is also useful in evaluating adrenal function and distinguishing between ovarian and adrenal sources of androgen excess. Additionally, androstenedione measurement can aid in assessing pubertal disorders and adrenal insufficiency.
Frequently asked questions
Do I need to fast before the androstenedione test?
What are the normal reference ranges for androstenedione?
Can androstenedione levels change throughout the day?
What conditions are associated with high androstenedione?
Sources
- 1
- 2
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 15, 2026. · Read our editorial policy