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Angiotensiniiplasmcnc

Published: August 9, 2026Updated: August 16, 2026

A blood test that measures the level of angiotensin II, a hormone that helps regulate blood pressure and fluid balance in your body.

Quick summary

{"Measures angiotensin II hormone in your blood plasma","Helps diagnose the cause of high blood pressure or low blood pressure","Evaluates how well your kidneys and hormones are working together to control blood pressure","Requires a simple blood sample drawn from a vein","Results help doctors understand if hormonal imbalances are causing your blood pressure problems"}

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
1860-6
Short code
ANGII
Synonyms
Angiotensin II Plas-mCnc
Category
chemistry
Sample
plasma
Container
Lavender-top (EDTA) tube with aprotinin or specific angiotensin II collection tube, kept cold
Units
N/A
Ref low
10
Ref high
60
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
Radioimmunoassay (RIA) or Enzyme Immunoassay (EIA)
CPT
82164
SNOMED
52805005
Specimen volume
3 mL plasma
Stability
Plasma stable for 2 weeks at -20°C; process and freeze immediately after collection
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
48–168 hours
Order
routine

What is this test?

The plasma angiotensin II test measures the amount of angiotensin II in your blood. Angiotensin II is a hormone produced by your body that plays a key role in regulating blood pressure and fluid balance. It causes blood vessels to narrow (vasoconstriction) and signals your kidneys to retain salt and water, both of which increase blood pressure. This test helps doctors understand how well your renin-angiotensin-aldosterone system (RAAS) is working.

Why do I need this test?

Your doctor may order this test if you have abnormal blood pressure readings, especially high blood pressure (hypertension) that is difficult to control. It can help determine if your high blood pressure is caused by hormonal problems rather than lifestyle factors. The test is also useful for evaluating kidney problems, adrenal gland disorders, and certain conditions that affect blood pressure regulation.

How is the test performed?

A healthcare professional will draw a small sample of blood from a vein in your arm using a needle. The blood is collected into a special tube and sent to a laboratory for analysis. You may need to fast (not eat or drink) for a certain period before the test, and your doctor may ask you to stop taking certain medications that could affect the results. The procedure only takes a few minutes and is generally well tolerated.

What do the results mean?

Angiotensin II levels that are too high may indicate conditions such as essential hypertension, renal artery stenosis (narrowing of kidney arteries), heart failure, or certain adrenal gland tumors. Low levels may be seen in conditions like diabetes insipidus, adrenal insufficiency, or as a side effect of certain blood pressure medications. Your doctor will interpret your results together with other tests and your overall health condition to make an accurate diagnosis.

Reference range

10-60 pg/mL (supine); may be higher in upright positionN/A

Specimen: plasma

No fasting required. Patient should maintain normal sodium intake prior to collection. Avoid excessive salt restriction or loading. Avoid strenuous exercise before collection.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Frequently asked questions

Do I need to fast before the test?
Yes, you may be asked to fast for 8-12 hours before the blood test. Your doctor will provide specific instructions. Some medications, especially blood pressure drugs, may need to be adjusted or stopped before the test. Always inform your doctor about all medications you are taking.
Will the test be painful?
You may feel a brief pinch or sting when the needle is inserted into your arm. Some people experience mild bruising afterward, but serious complications are rare. The discomfort is usually minimal and lasts only a few seconds.
How long does it take to get results?
Results are typically available within a few days to a week, depending on the laboratory. Your doctor's office will contact you with the results or discuss them at your follow-up appointment.
What conditions can affect angiotensin II levels?
Several factors can influence angiotensin II levels, including certain medications (especially ACE inhibitors, ARBs, and diuretics), kidney function, adrenal gland disorders, diet (especially salt intake), body position during the test, and time of day. It's important to follow your doctor's instructions carefully before the test.
  1. 1
    MedlinePlus - Angiotensin IISource
  2. 2
    Mayo Clinic Laboratories - Angiotensin II, PlasmaSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy