Angiotensiniisupplasscnc
This test measures the level of angiotensin II, a hormone that helps control blood pressure and fluid balance, in your blood while lying down.
{"Angiotensin II is a hormone that regulates blood pressure and blood volume","The test helps diagnose causes of high blood pressure and certain kidney disorders","Blood is drawn while you lie down (supine position) for accurate baseline measurement"}
Key facts at a glance
- LOINC
- 25562-0
- Short code
- ANGII-S
- Synonyms
- Angiotensin II sup Plas-sCnc
- Category
- chemistry
- Sample
- plasma
- Container
- Pre-chilled EDTA plasma tube (lavender-top) with aprotinin or other protease inhibitor added; alternatively, pre-chilled EDTA tube with samples transported on ice
- Units
- N/A
- Ref low
- 10
- Ref high
- 30
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 0–120 years
- Method
- Radioimmunoassay (RIA) or Enzyme Immunoassay (EIA)
- CPT
- 82164
- SNOMED
- 104686000
- Specimen volume
- 3-5 mL of whole blood collected into chilled tube
- Stability
- Plasma should be separated immediately in a refrigerated centrifuge and frozen at -20°C or lower; stable for up to 1 month at -20°C; avoid repeated freeze-thaw cycles
- Hemolysis max
- 50
- Lipemia max
- 100
- Icterus max
- 20
- TAT
- 24–96 hours
- Order
- routine
What is this test?
The Angiotensin II test measures the amount of a hormone called angiotensin II in your blood. Angiotensin II is a key part of the renin-angiotensin-aldosterone system (RAAS), which helps regulate your blood pressure and the balance of fluids and salts in your body. The 'supine' part means your blood sample is taken while you are lying down, which provides a consistent baseline measurement.
Why is it done?
This test is typically ordered to help diagnose the cause of high blood pressure (hypertension) that is difficult to control. It can also help identify conditions affecting the kidneys or adrenal glands, such as primary aldosteronism (overproduction of aldosterone) or renal artery stenosis (narrowing of kidney arteries). Your doctor may also use this test to evaluate certain types of kidney disease or to distinguish between different causes of high blood pressure.
How is the test performed?
A healthcare professional will draw a blood sample from a vein in your arm while you are lying down in a supine position. You may be asked to rest in this position for a period before the blood draw to ensure accurate results. The sample is then sent to a laboratory for analysis. You may need to fast or avoid certain medications before the test—follow your doctor's specific instructions.
Are there any risks?
The risks of this test are minimal and similar to routine blood tests. You may experience slight pain, bruising, or bleeding at the puncture site. In rare cases, infection or fainting may occur. These risks are generally low and temporary.
Reference range
Supine reference range: approximately 10-30 pg/mL (10-30 ng/L) for healthy adults; pediatric ranges may vary by ageN/A
Patient should be on a normal sodium diet prior to collection. Avoid excessive salt intake or restriction for at least 3 days before testing. Diuretics, ACE inhibitors, ARBs, beta-blockers, and NSAIDs should be discontinued if possible (consult physician). Patient must remain supine for at least 30 minutes prior to and during specimen collection.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Frequently asked questions
Do I need to prepare for the test?
What do high angiotensin II levels mean?
What do low angiotensin II levels mean?
Why is the test done in the supine position?
Will I need other tests?
Sources
- 1
- 2MedlinePlus - ReninSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 15, 2026. · Read our editorial policy