Angiotensiniplasmcnc
A blood test that measures the level of Angiotensin I in your plasma, which helps evaluate how your body's blood pressure regulation system is working.
{"Angiotensin I is a hormone that helps control blood pressure and fluid balance","This test helps doctors diagnose conditions affecting the renin-angiotensin system","The test requires a blood sample, usually drawn from a vein in your arm","Certain medications can affect test results, so inform your doctor about all medications","Results are often interpreted together with other tests like renin and aldosterone"}
Key facts at a glance
- LOINC
- 1858-0
- Short code
- ANG1
- Synonyms
- Angiotensin I Plas-mCnc
- Category
- chemistry
- Sample
- plasma
- Container
- Pre-chilled lavender top (EDTA) tube for plasma renin activity; or specialized tubes provided by reference laboratory
- Units
- N/A
- Ref low
- 0.2
- Ref high
- 2.3
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) or Radioimmunoassay (RIA)
- CPT
- 82164
- SNOMED
- 11562009
- Specimen volume
- 3-5 mL of plasma; minimum 1 mL required for analysis
- Stability
- Plasma should be separated immediately and frozen at -20°C or colder. Stable for 2 weeks at -20°C; up to 6 months at -70°C. Avoid repeated freeze-thaw cycles.
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 24–168 hours
- Order
- routine
What is this test?
The Angiotensin I test measures the amount of a hormone called Angiotensin I in your blood. Angiotensin I is part of the renin-angiotensin-angiotensin system (RAAS), which plays a crucial role in regulating your blood pressure, blood volume, and fluid balance in your body. This system involves a cascade of hormones and enzymes that work together to maintain healthy blood pressure levels.
Why is it ordered?
Your doctor may order this test to help diagnose or monitor conditions that affect blood pressure regulation, such as hypertension (high blood pressure), adrenal gland disorders, kidney problems, or certain types of heart disease. It may also be used to evaluate the cause of low blood pressure or to assess how well certain blood pressure medications are working. The test is often performed alongside other tests like plasma renin activity and aldosterone levels to get a complete picture of your RAAS function.
How is the test performed?
A healthcare professional will draw a small sample of blood from a vein in your arm using a needle. The blood will be collected into a special tube containing an enzyme inhibitor to prevent the breakdown of Angiotensin I. You may feel a brief pinch or sting when the needle is inserted. The blood sample is then sent to a laboratory for analysis. The procedure usually takes only a few minutes, and you can return to your normal activities immediately after the blood draw.
How to prepare for the test?
Your doctor may ask you to stop taking certain medications before the test, as many common blood pressure drugs can affect Angiotensin I levels. These may include ACE inhibitors, ARBs, diuretics, and beta-blockers. You may also need to fast (not eat or drink) for a certain period before the test, typically 8-12 hours. Additionally, you should inform your doctor about all medications, supplements, and herbal products you are taking. It is important to follow your doctor's specific instructions carefully to ensure accurate results.
Understanding your results
Normal Angiotensin I levels can vary depending on the laboratory and the specific methods used. Your doctor will interpret your results in the context of your overall health, symptoms, and other test results. Abnormally high or low levels may indicate various conditions that require further evaluation. It is important to discuss your specific results with your healthcare provider, who can explain what they mean for your individual health situation.
Reference range
Reference values vary by methodology and laboratory; consult your laboratory's specific reference interval. Typical ranges: Supine: 0.2-2.3 ng/mL/hr; Upright: 0.7-3.3 ng/mL/hr (when reported as angiotensin I generation rate). For direct mass/volume measurement: typically <50 pg/mL in normal adults on normal sodium intake.N/A
No fasting required. Patients should be on a normal sodium diet prior to testing. Avoid excessive salt intake or restriction for at least 3 days before collection. Certain medications (ACE inhibitors, ARBs, diuretics, beta-blockers, NSAIDs) may affect results; consult physician regarding medication management prior to testing. Avoid licorice ingestion and tobacco use before collection.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Frequently asked questions
Is the test safe?
How long does it take to get results?
Do I need to fast before the test?
Can I take my regular medications before the test?
What happens if my results are abnormal?
Sources
- 1
- 2
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy