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Serum Angiotensinogen Concentration

Published: August 9, 2026Updated: August 15, 2026

This test measures the amount of angiotensinogen, a protein in your blood that plays a role in regulating blood pressure and fluid balance. It may be checked to help diagnose or monitor conditions affecting these systems.

Quick summary

["Angiotensinogen levels can help assess kidney function and blood pressure regulation."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 15, 2026Editorial policy

Key facts at a glance

LOINC
47087-2
Short code
ANGN
Synonyms
Angiotensinogen Plas-sCnc
Category
chemistry
Sample
plasma
Container
Plasma separator tube (PST) with lithium heparin or EDTA tube; plasma separator tube preferred
Units
N/A
Ref low
500
Ref high
2000
Fasting
false
Population
adult
Sex
all
Age range
≥ 18 years
Method
Enzyme-linked immunosorbent assay (ELISA) or Radioimmunoassay (RIA)
CPT
82164
SNOMED
104212000
Specimen volume
1-2 mL of plasma (minimum 0.5 mL)
Stability
Plasma stable for 2 hours at room temperature; 24 hours at 2-8°C; 1 month at -20°C or below for long-term storage. Avoid repeated freeze-thaw cycles.
Hemolysis max
50
Lipemia max
100
Icterus max
25
TAT
48–168 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test if you have symptoms or risk factors for conditions like kidney disease, high blood pressure, or certain genetic disorders. It may also be used to monitor treatment progress for conditions linked to angiotensinogen levels.

What Does the Result Mean?

Results are not typically interpreted alone but are often compared to your clinical picture, including symptoms, medical history, and other test results. Abnormal levels might suggest underlying health concerns needing further evaluation.

How Is the Test Performed?

A blood sample is drawn from a vein, usually in your arm. The blood is processed to separate serum, which is then tested for angiotensinogen concentration using a specialized laboratory method.

What Are Common Causes of Abnormal Results?

Low levels may be linked to kidney disease, liver problems, or certain genetic conditions. High levels could be associated with conditions affecting fluid balance or rare genetic disorders. Always discuss results with your provider.

Reference range

Reference values vary by methodology; consult laboratory-specific reference range. Typical plasma angiotensinogen concentrations range from approximately 500-2000 ng/mL (or method-dependent equivalent in pmol/L).N/A

Specimen: plasma

No special patient preparation required. Patients should maintain normal sodium intake prior to collection. Avoid strenuous exercise before specimen collection. If on antihypertensive medications, consult physician regarding potential need to withhold ACE inhibitors or ARBs.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Angiotensinogen is a precursor protein in the renin-angiotensin system, which helps control blood pressure and fluid retention. Abnormal levels may indicate kidney dysfunction, hereditary conditions like hyperangiotensinogenemia, or other metabolic disorders requiring further investigation.

Short name

Angiotensinogen Level

Frequently asked questions

What does a high or low angiotensinogen level indicate?
A high level may suggest conditions like liver disease, certain genetic disorders, or fluid overload, while low levels could indicate kidney problems or other metabolic issues. Your provider will interpret results in the context of your overall health.
How often should I get this test?
Frequency depends on your medical needs. Your healthcare provider will determine how often this test is necessary based on your symptoms, medical history, and treatment plan.
Can lifestyle changes affect angiotensinogen levels?
While diet, exercise, and hydration can influence overall health, direct effects on angiotensinogen levels are less well-documented. Always follow your provider’s advice regarding lifestyle modifications.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 15, 2026. · Read our editorial policy