Antibody to *Aspergillus* (Serum) – Immunoassay
This test detects antibodies in your blood that may indicate exposure to the fungus *Aspergillus*, a common mold found in soil and decaying organic matter. It helps identify past or potential allergic or infectious responses.
["This test checks for immune system reactions to *Aspergillus* exposure, often used in allergy or fungal infection evaluations."]
Key facts at a glance
- LOINC
- 44030-5
- Short code
- ASPNIDAB
- Synonyms
- A nidulans H Ab Ser Ql ID
- Category
- chemistry
- Sample
- serum
- Container
- Red-top serum collection tube (no anticoagulant) or serum separator tube (SST) with gel barrier. Collect in a standard vacutainer tube, allow to clot for 30 minutes at room temperature, then centrifuge.
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- immune-diffusion
- CPT
- 86606
- SNOMED
- 252450006
- Specimen volume
- 1-2 mL of serum (minimum 0.5 mL). Standard venipuncture collection of 5-10 mL whole blood typically yields adequate serum volume.
- Stability
- Serum is stable for 7 days when stored at 2-8°C (refrigerated). For extended storage beyond 7 days, freeze at -20°C or lower (-70°C preferred for long-term storage). Avoid repeated freeze-thaw cycles as this may degrade immunoglobulin integrity and produce false-negative results.
- Hemolysis max
- 200
- Lipemia max
- 100
- Icterus max
- 40
- TAT
- 48–168 hours
- Order
- routine
Why This Test Might Be Ordered
Your healthcare provider may recommend this test if you have symptoms like persistent cough, wheezing, or lung issues that could suggest an allergic reaction or infection from *Aspergillus*. It may also be used in patients with weakened immune systems or those with conditions like asthma, cystic fibrosis, or chronic lung diseases.
What to Expect Before the Test
No special preparation is needed. You’ll provide a blood sample, typically drawn from your arm. If you’re on blood-thinning medication, let your provider know before the test.
What the Results Mean
Positive results suggest the presence of antibodies, which may indicate past exposure or an immune response to *Aspergillus*. However, antibodies alone don’t confirm an active infection. Results are often interpreted alongside clinical symptoms and other tests.
Common Causes of Positive Results
Positive results can occur from exposure to *Aspergillus* spores (common in outdoor or indoor environments), allergic reactions, or past infections. Some people may have naturally higher antibody levels without symptoms.
Reference range
Negative: No precipitin lines observed, indicating absence of detectable Aspergillus nidulans-specific antibodies. Positive: One or more precipitin lines observed, indicating presence of IgG antibodies specific to Aspergillus nidulans antigens.N/A
No fasting required. No special patient preparation is necessary. Patients on immunosuppressive therapy, systemic corticosteroids, or those with known immune deficiencies may produce false-negative results due to diminished antibody response. Recent antifungal therapy may reduce antibody titers.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
This test is primarily used to assess immune responses to *Aspergillus*, guiding decisions about further evaluation (e.g., fungal cultures, imaging) or management of suspected allergic or infectious conditions. It’s not a direct diagnostic for active disease but can help identify patients at higher risk for complications.
Short name
Aspergillus Antibody (Serum)
Frequently asked questions
What does a positive result mean for my health?
Can I get this test at home?
How long will it take to get my results?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 15, 2026. · Read our editorial policy