Skip to content

Serum or Plasma Immunoassay for Angiotensinogen

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of angiotensinogen, a protein produced by the liver that helps regulate blood pressure and fluid balance. It may be checked if you have conditions like polycystic ovary syndrome (PCOS), liver disease, or unexplained high blood pressure.

Quick summary

["Angiotensinogen levels can help diagnose or monitor conditions affecting blood pressure regulation and liver function."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
110982-6
Short code
ASPNAB
Synonyms
A niger Ab Msmt Ser
Category
chemistry
Sample
serum
Container
Serum separator tube (SST) or red-top vacutainer tube
Units
N/A
Ref low
0.35
Ref high
0.5
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
Immunoassay (EIA/ELISA)
CPT
86606
SNOMED
39513008
Specimen volume
1.0 mL serum (minimum 0.5 mL)
Stability
Room temperature: 8 hours; Refrigerated (2-8°C): 7 days; Frozen (-20°C or below): 30 days. Avoid repeated freeze-thaw cycles.
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
24–72 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may order this test if you have symptoms or risk factors linked to angiotensinogen-related conditions, such as: - Unexplained high blood pressure (hypertension). - Liver disease or cirrhosis. - Polycystic ovary syndrome (PCOS), especially if hormonal imbalances are suspected. - Family history of conditions affecting protein metabolism or blood pressure.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast for 8–12 hours before the test if instructed. Bring any medications you’re taking, as some may affect results. Your blood will be drawn from a vein in your arm.

How the Test Works

A small sample of your blood (serum or plasma) is taken and analyzed using an immunoassay method. This test detects the presence and quantity of angiotensinogen in your bloodstream by measuring its interaction with specific antibodies.

What the Results Mean

Results are typically reported as a ratio or index compared to a reference range (if available). Elevated levels may suggest conditions like liver disease or PCOS, while lower levels could indicate genetic variants or other metabolic issues. Always discuss results with your provider.

Reference range

Negative: <0.35; Equivocal: 0.35-0.50; Positive: >0.50 (Interpretation based on assay-specific index values or arbitrary units; results should be interpreted in conjunction with clinical findings and other diagnostic tests such as Aspergillus galactomannan and culture.)N/A

Specimen: serum

No fasting required. No special patient preparation is necessary. Patients on antifungal therapy or immunosuppressants should be noted, as these may affect antibody levels.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Abnormal angiotensinogen levels can provide clues about underlying health conditions. For example: - High levels may be linked to liver dysfunction or certain genetic disorders. - Low levels could be associated with conditions affecting protein synthesis or hormonal imbalances. Your provider will interpret results in the context of your overall health and symptoms.

Short name

Angiotensinogen Level

Frequently asked questions

What causes angiotensinogen levels to change?
Several factors can influence angiotensinogen levels, including liver disease, hormonal imbalances (like those in PCOS), certain medications, or genetic predispositions. Stress, diet, and chronic conditions such as hypertension may also play a role.
How often should I get this test?
The frequency depends on your medical needs. Your healthcare provider will determine how often to check this test based on your symptoms, diagnosis, or monitoring plan—typically every few months to a year if ordered regularly.
Can diet or lifestyle changes affect this test result?
Yes, diet, hydration, and certain medications (like blood pressure drugs) can influence angiotensinogen levels. Avoiding alcohol and following your provider’s fasting instructions can help ensure accurate results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy