Angiotensinogen (Serum) Mass Concentration
This test measures the amount of angiotensinogen, a protein in your blood that plays a role in regulating blood pressure and fluid balance.
["Angiotensinogen helps control your blood pressure and fluid levels; levels may be checked for conditions like liver disease or hereditary angioedema."]
Key facts at a glance
- LOINC
- 56181-1
- Short code
- ASPNG4
- Synonyms
- A niger IgG4-mCnc
- Category
- chemistry
- Sample
- serum
- Container
- Serum separator tube (SST) or red-top tube
- Units
- N/A
- Ref low
- 0
- Ref high
- 0.35
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- Enzyme Immunoassay (EIA) / ImmunoCAP FEIA
- CPT
- 86001
- SNOMED
- 395141001
- Specimen volume
- 1.0 mL serum (minimum 0.5 mL)
- Stability
- Room temperature: 8 hours; Refrigerated (2-8°C): 7 days; Frozen (-20°C or below): 1 month. Avoid repeated freeze-thaw cycles.
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 48–168 hours
- Order
- routine
Why Is This Test Done?
Your healthcare provider may order this test to evaluate liver function, monitor conditions affecting protein production, or investigate symptoms like swelling, high blood pressure, or unexplained fatigue. It can also help diagnose or manage hereditary angioedema, a rare genetic disorder causing sudden swelling.
What Does a Result Mean?
Results may vary based on health status and lab standards. High levels could suggest liver disease or certain genetic conditions, while low levels might indicate liver dysfunction or hereditary angioedema. Your provider will interpret results in the context of your overall health and symptoms.
How Is the Test Performed?
A blood sample is drawn from a vein, usually in your arm. The sample is sent to a lab where it is analyzed to measure angiotensinogen concentration using a specialized technique.
What Should You Do Before the Test?
Avoid alcohol for 24 hours before testing, as it may affect liver function and, indirectly, angiotensinogen levels. Fast if instructed, but confirm with your provider. Wear comfortable clothing and bring any medications or supplements you’re taking.
Reference range
Reference range varies by laboratory and assay methodology. Generally, <0.35 mg/L or negative is considered normal; results should be interpreted in conjunction with clinical findings and other allergen-specific IgE/IgG testing.N/A
No special patient preparation required. Fasting is not necessary.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Short name
Serum Angiotensinogen Level
Frequently asked questions
Elevated levels may indicate liver disease (e.g., cirrhosis) or hereditary angioedema, where low levels are associated with the condition. Abnormal results often prompt further testing or evaluation of symptoms like swelling, recurrent abdominal pain, or respiratory issues.
No special preparation is usually required, but follow any instructions from your healthcare provider. If you have liver disease or take medications affecting protein levels, inform your lab staff.
Results are typically available within 1–3 business days, depending on your lab’s processing time. Your provider will discuss findings with you during your follow-up visit.
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy