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Antibody to *Treponema pallidum* (serum/plasma, qualitative)

Published: August 9, 2026Updated: August 16, 2026

This test detects antibodies that your body produces in response to the bacteria *Treponema pallidum*, which causes syphilis. It helps identify if you may have been exposed to the infection.

Quick summary

["This screening test can help determine if you need further testing for syphilis."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
5370-2
Short code
ASO Ab SerPl-aCnc
Synonyms
ASO Ab SerPl-aCnc
Category
coagulation
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test looks for specific antibodies (proteins) in your blood that your immune system creates when it encounters *Treponema pallidum*. These antibodies are a sign that your body has either already fought off the infection or is still responding to it. This test is qualitative, meaning it only tells you if antibodies are present or not, rather than how much.

Why It’s Done

Doctors may recommend this test if you have symptoms of syphilis, such as sores, rashes, or other unusual changes in your body. It’s also used as a screening test for people at higher risk of infection, such as those with multiple sexual partners, those with sexually transmitted infections (STIs), or those who have unprotected sex.

What to Expect Before the Test

No special preparation is needed for this test. You may have a small needle inserted into your arm to draw blood. The process usually takes a few minutes, and you can return to your normal activities afterward.

What the Results Mean

If the test is positive, it means your body has detected antibodies to *Treponema pallidum*, suggesting past or current infection. A positive result does not always mean you have active syphilis, but it warrants further testing to confirm. If the result is negative, it means no detectable antibodies were found at this time.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Syphilis Antibody Screen (Serum/Plasma)

Frequently asked questions

What does a positive result mean?
A positive result on this screening test means you may have been exposed to syphilis. You should discuss your results with your healthcare provider, who may recommend additional tests, such as a confirmatory *Treponema pallidum* antibody test or a nucleic acid amplification test (NAAT) if applicable. Early treatment can prevent serious health complications.
Can I have false positives or negatives?
False positives are rare but possible, especially if you have been previously exposed to other infections or have certain medical conditions. False negatives can occur if the test was done too early after exposure or if the infection is in a very early or advanced stage. Your healthcare provider will guide you on what to do next based on your results and symptoms.
How often should I get this test?
The frequency of this test depends on your risk factors. If you are at higher risk for syphilis (e.g., due to sexual history or STI exposure), your healthcare provider may recommend retesting within a few months. If you are pregnant, this test is often done as part of routine prenatal care to ensure the health of both you and your baby.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy