Antibody to *Treponema pallidum* (serum/plasma, qualitative)
This test detects antibodies that your body produces in response to the bacteria *Treponema pallidum*, which causes syphilis. It helps identify if you may have been exposed to the infection.
["This screening test can help determine if you need further testing for syphilis."]
Key facts at a glance
- LOINC
- 5370-2
- Short code
- ASO Ab SerPl-aCnc
- Synonyms
- ASO Ab SerPl-aCnc
- Category
- coagulation
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What This Test Measures
The test looks for specific antibodies (proteins) in your blood that your immune system creates when it encounters *Treponema pallidum*. These antibodies are a sign that your body has either already fought off the infection or is still responding to it. This test is qualitative, meaning it only tells you if antibodies are present or not, rather than how much.
Why It’s Done
Doctors may recommend this test if you have symptoms of syphilis, such as sores, rashes, or other unusual changes in your body. It’s also used as a screening test for people at higher risk of infection, such as those with multiple sexual partners, those with sexually transmitted infections (STIs), or those who have unprotected sex.
What to Expect Before the Test
No special preparation is needed for this test. You may have a small needle inserted into your arm to draw blood. The process usually takes a few minutes, and you can return to your normal activities afterward.
What the Results Mean
If the test is positive, it means your body has detected antibodies to *Treponema pallidum*, suggesting past or current infection. A positive result does not always mean you have active syphilis, but it warrants further testing to confirm. If the result is negative, it means no detectable antibodies were found at this time.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance
Short name
Syphilis Antibody Screen (Serum/Plasma)
Frequently asked questions
What does a positive result mean?
Can I have false positives or negatives?
How often should I get this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy