Atorvastatin-Neutralizing IgG Antibodies, Serum/Plasma — Qualitative
A specialized blood test that detects atorvastatin-neutralizing IgG antibodies, which may be associated with an uncommon immune-mediated muscle disorder.
["Detected antibodies can support investigation of statin-related immune-mediated muscle injury, but the result must be interpreted with symptoms and other tests."]
Key facts at a glance
- LOINC
- 73054-9
- Short code
- Atorvastatin (neut) IgG SerPl Ql FC
- Synonyms
- Atorvastatin (neut) IgG SerPl Ql FC
- Category
- liver
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 10
- Ref high
- 40
- Critical range
- — – 500 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- flow-cytometry
- CPT
- 84484
- SNOMED
- 302774002
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What is this test?
This qualitative blood test looks for IgG antibodies that neutralize atorvastatin, a cholesterol-lowering statin. It is a specialized test and is not the same as a routine atorvastatin drug-level test.
Why might I need this test?
It may be considered when a patient develops unusual or severe muscle weakness, muscle pain, or elevated muscle enzymes after taking atorvastatin, especially when an immune-mediated necrotizing myopathy is suspected.
How is the test performed?
A blood sample is collected and tested in a specialized laboratory for atorvastatin-neutralizing IgG antibodies. The report generally indicates whether the antibodies were detected or not detected.
How do I prepare for the test?
No special preparation or fasting is usually required. Tell the laboratory and your clinician about all statin medications you have taken, but do not stop prescribed medication without medical guidance.
Reference range
Adult: 10-40 U/LN/A
No special preparation required. Avoid fatty meals before the test if possible.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Detecting these antibodies may support an immune-mediated reaction to atorvastatin, particularly in patients with persistent or severe muscle symptoms and elevated muscle enzymes. However, a detected result does not by itself establish the diagnosis and must be interpreted with medication history, examination findings, and other laboratory tests. A negative result does not completely exclude statin-associated immune-mediated muscle disease.
Short name
Atorvastatin-neutralizing IgG antibodies
Frequently asked questions
What does a positive result mean?
Is this a routine statin blood test?
Should I stop taking atorvastatin before the test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy