Serum or plasma concentration of β2-glycoprotein I (β2-GPI) by immunoassay
This test measures the level of β2-glycoprotein I, a protein found in your blood that plays a role in blood clotting and immune system function. It may be checked to evaluate conditions like antiphospholipid syndrome or other autoimmune disorders.
["Your β2-GPI level helps assess risks related to blood clots or autoimmune conditions."]
Key facts at a glance
- LOINC
- 56152-2
- Short code
- B2 glycoprot 1 IgA+IgG+IgM Pnl Ser
- Synonyms
- B2 glycoprot 1 IgA+IgG+IgM Pnl Ser
- Category
- glucose
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 82784
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Might Be Ordered
Your healthcare provider may recommend this test if you have symptoms like unexplained blood clots, recurrent miscarriages, or other signs of autoimmune disease. It could also be part of a broader evaluation for conditions like lupus or other connective tissue disorders.
What to Expect Before the Test
No special preparation is usually needed. You may have blood drawn from a vein in your arm, similar to other blood tests. If you’re on blood thinners, let your provider know before the test.
What the Results Mean
Results are typically reported as a concentration value (e.g., in grams per liter). While reference ranges vary by lab, elevated or low levels may suggest certain autoimmune or clotting disorders. Your provider will interpret results in the context of your overall health and symptoms.
Common Conditions Linked to β2-GPI
High levels of β2-GPI are often associated with antiphospholipid syndrome (APS), a condition where the immune system mistakenly attacks blood clots. It may also be linked to other autoimmune diseases like systemic lupus erythematosus (SLE).
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical significance: Elevated β2-GPI levels are frequently linked to antiphospholipid antibodies, which can increase the risk of blood clots, pregnancy complications, or chronic inflammation. Low levels alone are less commonly significant but may warrant further investigation if symptoms suggest an underlying issue.
Short name
β2-GPI Level
Frequently asked questions
What causes β2-GPI levels to change?
Is there a standard reference range for β2-GPI?
Can diet or lifestyle affect β2-GPI test results?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy