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B2-Glycoprotein I (B2GPI) Immunoglobulin G (IgG) Antibody Test

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of antibodies against B2-glycoprotein I (B2GPI) in your blood. These antibodies are sometimes linked to certain autoimmune conditions.

Quick summary

["Your doctor may order this test to help diagnose or monitor conditions like antiphospholipid syndrome."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
72488-0
Short code
B2 glycoprot 1 IgG+IgM pnl Ser
Synonyms
B2 glycoprot 1 IgG+IgM pnl Ser
Category
glucose
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does This Test Measure?

B2GPI is a protein found in your blood that plays a role in blood clotting. Antibodies against B2GPI can be detected in people with certain autoimmune disorders, including antiphospholipid syndrome, lupus anticoagulant, or thrombocytopenia. This test specifically looks for IgG antibodies against B2GPI.

Why Might You Need This Test?

Your healthcare provider may recommend this test if you have symptoms like unexplained blood clots, recurrent miscarriages, or other signs of autoimmune diseases. It can also be used to monitor these conditions over time.

Sample Collection and Preparation

A blood sample is taken from a vein in your arm. The blood is processed to separate the serum (liquid part of blood without clotting factors) for testing. This test is typically done using an immunoassay method to detect the presence of IgG antibodies.

What to Expect Before the Test

There are no special preparations needed for this test. You can eat, drink, and take your usual medications as usual. If you are on blood thinners, inform your healthcare provider before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Elevated levels of B2GPI IgG antibodies may indicate an increased risk of developing autoimmune-related blood clotting disorders. While not all positive results mean you have a specific condition, they can prompt further evaluation. Your doctor will consider the test results along with your symptoms and medical history to make a diagnosis.

Short name

B2GPI IgG Antibody

Frequently asked questions

What does a positive result mean?
A positive result for B2GPI IgG antibodies means your immune system has detected these antibodies in your blood. This can be a marker for certain autoimmune conditions, but it doesn’t always mean you have a specific disease. Your doctor will discuss the next steps, which may include additional tests or monitoring.
Can lifestyle changes affect this test?
Generally, lifestyle changes like diet or exercise do not directly affect antibody levels measured by this test. However, managing any underlying conditions or symptoms you have can be important for overall health and may influence how your test results are interpreted.
How often will I need this test?
The frequency of this test depends on your medical condition and the recommendations of your healthcare provider. If you are being monitored for an autoimmune disorder, your doctor may schedule follow-up tests at regular intervals to check for changes in antibody levels.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy