Skip to content

Serum or Plasma Beta-2 Glycoprotein I Immunoglobulin Level (Quantitative)

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of a specific protein, beta-2 glycoprotein I, which is often studied in the context of certain autoimmune conditions or as part of blood screening.

Quick summary

This test helps assess potential autoimmune activity or exposure to certain conditions affecting blood proteins.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
44448-9
Short code
B2 Glycoprot1 IgG SerPl IA-aCnc
Synonyms
B2 Glycoprot1 IgG SerPl IA-aCnc
Category
glucose
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test if you have symptoms or risk factors related to autoimmune diseases, such as lupus or other connective tissue disorders. It may also be used to monitor treatment progress or investigate unexplained blood test abnormalities.

What Does This Test Measure?

Beta-2 glycoprotein I is a protein found in blood plasma. Elevated or altered levels can be associated with certain autoimmune conditions or may indicate exposure to specific antigens. This test quantifies its presence in your serum or plasma.

How Is the Sample Collected?

A blood sample is drawn from a vein, usually in your arm. The blood is then processed to separate the serum or plasma for testing.

What Are Possible Results?

Results are expressed in mass concentration units (e.g., grams per liter). Interpretation depends on clinical context and your healthcare provider’s guidance.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Beta-2 glycoprotein I is involved in blood clotting and immune responses. Elevated levels may be linked to autoimmune diseases like antiphospholipid syndrome or other conditions affecting blood proteins. Your provider will discuss findings in relation to your symptoms and medical history.

Short name

Beta-2 Glycoprotein I Antibody Test

Frequently asked questions

What does a high or low level of beta-2 glycoprotein I mean?
A high level may suggest an autoimmune response or other underlying condition, but results alone do not diagnose a specific condition. Your provider will review the test result alongside other factors, such as symptoms and lab tests.
How often should I get this test?
Frequency depends on your healthcare provider’s recommendations. Some patients may need this test periodically to monitor conditions or treatment effects.
Can lifestyle changes affect this test result?
While diet and activity may influence general health, they typically do not directly impact beta-2 glycoprotein I levels unless they affect conditions linked to this protein, such as autoimmune diseases.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy