Skip to content

Serum or Plasma β2-Glycoprotein I (β2-GPI) Mass Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of β2-glycoprotein I, a protein found in blood plasma that plays a role in blood clotting and immune system regulation. It may be checked to assess certain autoimmune conditions or vascular health.

Quick summary

["This test helps evaluate blood clotting and autoimmune risks."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
1880-4
Short code
B2 Glycoprot1 SerPl-mCnc
Synonyms
B2 Glycoprot1 SerPl-mCnc
Category
glucose
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test if you have symptoms or risk factors for autoimmune diseases (such as lupus or antiphospholipid syndrome) or if you have concerns about blood clotting disorders. It can also be part of routine monitoring for patients with known conditions affecting these proteins.

What Does the Result Mean?

Results are not typically provided as a single reference range since β2-GPI levels can vary based on health status and testing context. Abnormal levels may suggest an underlying condition requiring further evaluation by your doctor.

Sample Collection and Preparation

Blood is drawn from a vein, usually in your arm, and sent to a lab for processing. The sample is separated into serum (after clotting) or plasma (using an anticoagulant) before testing.

Common Conditions Monitored

This test may be used to monitor or diagnose conditions like antiphospholipid syndrome, lupus anticoagulant, or other autoimmune disorders where β2-GPI is implicated in disease mechanisms.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: β2-Glycoprotein I in Health and Disease

Short name

β2-Glycoprotein I

Frequently asked questions

What preparation is needed before the test?
No special preparation is usually required, but avoid consuming certain medications or supplements that may affect blood components 24 hours before testing if instructed by your provider.
How long does it take to get results?
Results are typically available within 1 to 3 business days, depending on the lab’s processing schedule.
Can I eat or drink before this test?
You can typically eat and drink normally unless your healthcare provider specifies otherwise, as this test does not require fasting.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy