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Transferrin in Cerebrospinal Fluid (CSF)

Published: August 9, 2026Updated: August 17, 2026

This test measures the protein transferrin found in your cerebrospinal fluid (the fluid surrounding your brain and spinal cord). Transferrin plays a role in iron transport in the body, and its presence in CSF can sometimes be evaluated in certain neurological or metabolic conditions.

Quick summary

["Transferrin in CSF may help assess rare metabolic or neurological disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
40610-8
Short code
B2TF
Synonyms
B2 Transferrin CSF Ql
Category
chemistry
Sample
csf
Container
Sterile CSF collection tube (polypropylene); sterile screw-cap container for leak specimens
Units
N/A
Ref low
200
Ref high
350
Fasting
false
Population
adult
Sex
all
Age range
≥ 0 years
Method
Immunofixation electrophoresis; Western blot; Nephelometry
CPT
86335
SNOMED
104879003
Specimen volume
1-2 mL of CSF or body fluid
Stability
Refrigerated (2-8°C): 7 days; Frozen (-20°C or below): 30 days; Room temperature: 24 hours
Hemolysis max
200
TAT
24–72 hours
Order
routine

Why Might This Test Be Ordered?

Your healthcare provider may order this test if you have symptoms or conditions that could be linked to abnormal transferrin levels in the CSF, such as certain genetic disorders affecting iron metabolism or rare neurological conditions. It may also be part of a broader evaluation for conditions like hereditary tyrosinemia or other metabolic diseases.

What Does This Test Involve?

A small amount of cerebrospinal fluid is collected through a procedure called a lumbar puncture (spinal tap). The fluid is then analyzed in a laboratory to measure transferrin levels.

Sample Collection and Preparation

The test requires a sterile needle to draw CSF from your lower back. You may feel a brief pinch, but the procedure is generally quick and well-tolerated. You’ll lie on your side with your knees bent, and the healthcare provider will insert the needle into the spinal canal.

What to Expect After the Test

After the procedure, you may experience mild soreness or a headache, which can be managed with rest, hydration, and sometimes medication. Avoid heavy lifting or strenuous activity for a few hours afterward to reduce the risk of complications.

Reference range

NCBI: Transferrin 200-350 mg/dLN/A

Specimen: csf

No fasting required. Specimen collection should be performed by lumbar puncture under sterile conditions by a qualified healthcare provider. For evaluation of CSF leak, fluid may be collected from nasal or ear discharge using sterile techniques.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

CSF Transferrin

Frequently asked questions

What does a low or high transferrin level in CSF mean?
Low levels of transferrin in CSF may suggest certain metabolic disorders or genetic conditions affecting iron metabolism, though this is not a definitive diagnosis. High levels are less commonly associated with transferrin and would require further evaluation by your healthcare provider to rule out other factors.
How often is this test repeated?
The frequency of this test depends on your symptoms, diagnosis, and healthcare provider’s recommendations. Some conditions may require repeated testing to monitor progression or response to treatment, while others may be one-time evaluations.
Can this test be done at home?
No, this test requires a specialized procedure called a lumbar puncture, which must be performed by a healthcare professional in a clinical setting. It cannot be done at home.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy