Beta-lactam Resistance Screening by KPC (Carbapenemase-Producing Klebsiella pneumoniae) DNA Probe Test
This test checks for the presence of genes that make certain bacteria resistant to powerful antibiotics called beta-lactams, including carbapenems. It helps healthcare providers determine if a bacterial infection may require different treatment options.
["Assists in identifying antibiotic-resistant bacteria that could require alternative treatments."]
Key facts at a glance
- LOINC
- 105783-5
- Short code
- KPCBC
- Synonyms
- Bac b-lactam res KPC Ct Bld + NAA prb
- Category
- chemistry
- Sample
- whole-blood
- Container
- Positive blood culture bottle (aerobic or anaerobic) flagged positive by continuous-monitoring blood culture instrument (e.g., BACTEC, BacT/ALERT). For subculture or direct testing, transfer to sterile screw-cap tube or manufacturer-specific NAA cartridge/tube.
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 0–120 years
- Method
- probe-amp-tar
- CPT
- 87641
- SNOMED
- 428531000124102
- Specimen volume
- 1-2 mL aliquot from positive blood culture bottle, or per manufacturer's instructions for the specific NAA assay (typically 0.2-1 mL transferred to reaction tube)
- Stability
- Test promptly after blood culture flags positive. If delayed, refrigerate positive broth at 2-8°C for up to 24 hours, or freeze at -70°C or below for longer storage. Avoid repeated freeze-thaw cycles.
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 1–4 hours
- Order
- routine
This test plays an important role in your care because it gives your healthcare team reliable information about how your body is working. The results help your doctor make accurate decisions about your diagnosis, guide treatment choices, and track your progress over time, so you receive the safest and most effective care possible.
Resistant bacteria can make infections harder to treat and may require stronger or different antibiotics. This test helps doctors decide the best course of action for your infection, ensuring you receive the most effective treatment possible.
The test is a straightforward procedure performed by trained medical staff. Depending on the type of test your doctor has ordered, it may involve providing a small sample, such as blood or urine, or undergoing a simple scan or measurement. Most tests take only a short time, and the staff will explain each step before it begins.
This test analyzes a small sample of your blood to detect specific genetic material (DNA) from bacteria known to produce KPC enzymes. The sample is processed to identify whether these resistant genes are present.
Your doctor uses the results to confirm or rule out a condition, adjust your medications, plan any additional testing that may be needed, and monitor how well your treatment is working. Together, you and your healthcare team can review the findings and decide on the next steps that best support your health.
If the test is positive, it suggests that the bacteria in your bloodstream may produce KPC enzymes, which can make certain antibiotics ineffective. This information guides your doctor in selecting appropriate antibiotics for your treatment.
Before the test, your care team will give you specific instructions, which may include fasting for a certain number of hours, avoiding certain medications or supplements, or drinking extra water. Tell the staff about any allergies, medications, or health conditions you have, and arrive on time with your identification and insurance information.
No special preparation is needed for this test. A healthcare provider will draw a small amount of blood from your arm, similar to a routine blood draw. The process is quick and usually painless.
Reference range
Negative (Ct value reported when positive; no Ct = target not detected). Typically reported as Detected, Not Detected, or Indeterminate.N/A
No special patient preparation required. Specimen is collected from a positive blood culture bottle; no direct patient fasting or preparation needed for the molecular test itself.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance: Understanding Resistance Patterns
Short name
KPC Resistance Screen
Frequently asked questions
This test is critical for managing infections caused by bacteria like *Klebsiella pneumoniae*, which can spread in healthcare settings. Detecting KPC resistance helps prevent the spread of antibiotic-resistant infections and ensures targeted treatment to improve recovery and reduce complications.
No special precautions are needed after the test. However, follow your doctor’s instructions regarding any antibiotics prescribed based on the test results. If you experience unusual symptoms or side effects, contact your healthcare provider immediately.
Results from this test are typically available within a few days to a week, depending on the laboratory’s processing time. Your doctor will discuss the results with you during your follow-up visit.
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy