Skip to content

Medical Test Overview: What to Expect and Why It Matters

Published: August 9, 2026Updated: August 16, 2026

A molecular test that detects genetic mutations in the gidB gene of bacteria to identify antibiotic resistance, specifically to streptomycin.

Quick summary

{"Detects mutations in the gidB gene that cause streptomycin resistance","Helps doctors choose effective antibiotics for treatment","Uses molecular methods to analyze bacterial DNA from a blood sample","Results guide personalized antibiotic therapy decisions","Important for managing difficult-to-treat bacterial infections"}

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
94061-9
Short code
GIDBDR
Synonyms
Bacterial gidB drug res mut Islt/Spm
Category
chemistry
Sample
serum
Container
Sterile, leak-proof specimen container; appropriate transport medium for bacterial culture or molecular testing
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
CPT
87556
SNOMED
398156007
Specimen volume
Minimum 1-2 mL of serum or appropriate specimen type for the clinical context; bacterial isolate preferred when available
Stability
Refrigerated at 2-8°C for up to 7 days; frozen at -70°C for longer storage; transport to laboratory within 24-48 hours of collection
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
24–168 hours
Order
routine

This is a diagnostic test that helps your healthcare provider evaluate your health, look for signs of illness, and guide decisions about your care. It may be ordered as part of a routine checkup or to investigate specific symptoms you have been experiencing.

This test looks for specific genetic changes (mutations) in the gidB gene of bacteria. The gidB gene is important because when it mutates, bacteria can become resistant to streptomycin, an antibiotic used to treat serious bacterial infections. By detecting these mutations early, doctors can avoid using antibiotics that won't work and choose more effective treatments.

The test is performed by a trained member of your care team, and the exact steps depend on the type of sample or measurement needed. Your provider will explain the process in advance, answer your questions, and help keep you comfortable throughout the procedure.

A blood sample is collected from you (serum). In the laboratory, scientists use molecular techniques to extract and analyze the bacterial DNA. They look specifically for changes or mutations in the gidB gene that are known to cause antibiotic resistance. The test is highly accurate and can detect even small amounts of resistant bacteria.

This test is important because it gives your healthcare provider reliable information about your condition, which helps confirm or rule out a diagnosis, monitor existing health problems, and choose the most appropriate treatment plan for your needs.

Antibiotic resistance is a growing problem worldwide. When bacteria become resistant to medications like streptomycin, infections become harder to treat. This test helps doctors quickly determine if a particular infection is resistant to certain antibiotics, allowing them to prescribe the most appropriate medication from the start. This improves treatment outcomes and helps prevent the spread of resistant bacteria.

Reference range

No mutations detected (wild-type gidB gene); presence of mutations reported individually with associated drug resistance interpretationN/A

Specimen: serum

No special patient preparation required. Specimen should be collected prior to initiation of antimicrobial therapy when possible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

The gidB gene mutation is specifically associated with resistance to streptomycin, an aminoglycoside antibiotic. Detecting these mutations is crucial for: (1) Guiding appropriate antibiotic selection for bacterial infections, (2) Preventing treatment failures from using ineffective antibiotics, (3) Managing infections caused by drug-resistant bacteria, (4) Supporting infection control measures in healthcare settings, and (5) Contributing to antimicrobial stewardship efforts.

Frequently asked questions

Does a positive result mean I cannot be treated?
No, a positive result for gidB gene mutations indicates streptomycin resistance, but there are many other antibiotics available. Your doctor will use this information to select an alternative antibiotic that will be effective against your specific infection.
How long does it take to get results?
Molecular tests typically provide results faster than traditional culture methods. Most laboratories can complete this test within 1-3 days, though this may vary depending on the laboratory.
Do I need to prepare for this test?
No special preparation is needed. Your blood sample will be collected by a healthcare professional, similar to routine blood tests.
Is this test only for streptomycin resistance?
This specific test targets the gidB gene, which is primarily associated with streptomycin resistance. Your doctor may order additional tests if resistance to other antibiotics is also suspected.
  1. 1
  2. 2

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy