Understanding Your Laboratory Blood Test: A Complete Patient Guide to Its Purpose, Procedure, and Results
This blood test measures gene activity to help determine if an infection is caused by bacteria or viruses and how severe inflammation is in your body.
{"Uses a blood sample to measure mRNA gene expression patterns","Helps distinguish between bacterial and viral infections","Assesses inflammation severity to guide treatment decisions","Results can help doctors decide if antibiotics are needed","Provides faster results than traditional culture methods"}
Key facts at a glance
- LOINC
- 112309-0
- Short code
- INF-MRP
- Synonyms
- Bact & vir & infl sev multi mRNA exp pnl Bld
- Category
- chemistry
- Sample
- serum
- Container
- PAXgene Blood RNA Tube (BD Diagnostics) — dedicated blood collection tube containing RNA stabilization reagent for whole blood mRNA preservation
- Units
- N/A
- Ref low
- 0
- Ref high
- 100
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 3–99 years
- Method
- Multigene mRNA Expression Profiling via Real-Time Reverse Transcription Polymerase Chain Reaction (RT-qPCR) with bioinformatics-based algorithmic scoring
- CPT
- 0115U
- SNOMED
- 433811000124104
- Specimen volume
- 2.5 mL whole blood collected directly into one PAXgene Blood RNA Tube (minimum 2.0 mL); note: LOINC lists serum but proprietary host-response panels typically use whole blood in RNA-stabilizing tubes
- Stability
- Whole blood in PAXgene tube: ambient temperature 14 days, refrigerated (2–8°C) 14 days, frozen at -20°C or -80°C up to 4 years post-RNA isolation. Isolated RNA: -80°C long-term. Avoid repeated freeze-thaw cycles.
- Hemolysis max
- 200
- Lipemia max
- 100
- Icterus max
- 40
- TAT
- 8–24 hours
- Order
- routine
This test is a laboratory examination, most often performed on a small sample of your blood, that measures specific substances in your body. Your healthcare provider uses the results to check how well your organs are working, screen for common conditions, and guide decisions about your ongoing care.
This test looks at how specific genes are expressed (how active they are) in your white blood cells. When your body fights an infection, different genes become more or less active depending on whether the infection is bacterial or viral. By measuring these patterns, the test can help your doctor understand what type of infection you have and how strongly your immune system is responding.
The test is usually done by drawing a small amount of blood from a vein in your arm. A trained technician cleans the site, wraps a band around your upper arm, inserts a thin needle, and collects the sample into a sealed tube. The procedure takes only a few minutes, and you may feel a brief pinch. Afterward, a small bandage is applied, and you can return to your normal activities right away.
A healthcare professional will draw a small amount of blood from a vein in your arm. The blood sample is then sent to a laboratory where scientists measure the activity levels of multiple genes related to infection and inflammation. The entire process is similar to a routine blood draw and typically takes only a few minutes.
Your doctor orders this test to help diagnose a medical condition, monitor an ongoing illness or the effectiveness of a treatment, or as part of a routine checkup. It provides important information about your health that cannot be seen during a physical exam alone, and it helps your care team detect potential problems early, often before symptoms appear.
Doctors may order this test when you have symptoms of an infection but it's unclear whether it's caused by bacteria or viruses. This is important because antibiotics only work against bacterial infections, not viral ones. Overusing antibiotics leads to antibiotic resistance, which is a growing health concern. This test helps doctors make more informed decisions about whether you need antibiotics.
Your results are compared with a standard reference range, and values within that range are considered typical. Results outside the range do not always mean you are ill; factors such as medications, diet, hydration, and stress can affect the numbers. Your healthcare provider will review the findings with you, explain what they mean in your situation, and recommend any follow-up testing or treatment if needed.
The test results will show patterns of gene activity that indicate: 1) Whether a bacterial or viral infection is more likely, and 2) The severity of inflammation in your body. Your doctor will interpret these results along with your symptoms, physical exam, and other test results to determine the best treatment plan for you.
Reference range
Interpretive scoring algorithm with categorical results (Bacterial likelihood score: Low/Moderate/High; Viral likelihood score: Low/Moderate/High; Inflammation severity index: 0-100 scale). Reference ranges vary by individual host gene expression signatures and clinical context; consult laboratory report for specific numerical thresholds.N/A
No fasting required. Specimen should be collected prior to administration of antibiotics, antivirals, or corticosteroids when clinically feasible to avoid suppression of host immune gene expression signatures. Avoid vigorous exercise for 24 hours prior to collection.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
This test helps healthcare providers distinguish between bacterial and viral infections, which is crucial for appropriate treatment. Bacterial infections typically require antibiotics, while viral infections usually need supportive care. Using this genetic signature test can reduce unnecessary antibiotic prescriptions, helping combat antibiotic resistance. Additionally, the inflammation severity measurement helps doctors assess how seriously your body is responding to an infection and can guide decisions about hospitalization or more aggressive treatment.
Frequently asked questions
Does this test tell me exactly what infection I have?
Do I need to fast before this test?
Are there any risks with this test?
How long does it take to get results?
Can this test be done on children?
Sources
- 1
- 2
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 14, 2026. · Read our editorial policy