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Barbitalmsmtserpl

Published: August 9, 2026Updated: August 16, 2026

A barbital blood test measures the amount of this barbiturate medication in your blood to ensure safe and effective dosing.

Quick summary

{"Barbital is a long-acting sedative medication used to treat anxiety and sleep disorders","This test checks if the drug level in your blood is within the therapeutic range","Regular monitoring helps prevent toxicity and ensures proper dosing","Blood is typically drawn from a vein in your arm","Results help your doctor adjust your medication if needed"}

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
109061-2
Short code
BARB
Synonyms
Barbital Msmt SerPl
Category
chemistry
Sample
serum
Container
Red-top serum tube (no anticoagulant) or plasma separator tube (PST)
Units
N/A
Ref low
2
Ref high
10
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
Gas Chromatography-Mass Spectrometry (GC-MS) or Immunoassay
CPT
80299
SNOMED
395152005
Specimen volume
2 mL serum or plasma
Stability
Room temperature: 24 hours; Refrigerated (2-8°C): 7 days; Frozen (-20°C or below): 30 days
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
24–72 hours
Order
routine

What is this test?

The barbital blood test measures the concentration of barbital in your serum or plasma. Barbital is a barbiturate medication that has been used as a sedative and hypnotic agent. While less commonly prescribed today compared to newer medications, it may still be used in certain situations to manage anxiety, tension, and sleep disorders. This test helps healthcare providers ensure that patients are receiving the correct dose and are not at risk for toxicity.

Why is this test performed?

Your doctor may order this test for several reasons: to monitor therapeutic drug levels in patients taking barbital, to check for signs of overdose or toxicity, to evaluate suspected poisoning cases, to ensure medication compliance, or to help diagnose the cause of unexplained symptoms such as excessive drowsiness, confusion, or breathing problems. The test is also useful in forensic and emergency settings when barbital overdose is suspected.

How is the test done?

A healthcare professional will draw a blood sample from a vein in your arm using a small needle. The procedure only takes a few minutes and may cause slight discomfort or bruising at the injection site. The blood sample is then sent to a laboratory for analysis. Depending on your situation, your doctor may ask you to have the test done at a specific time, such as just before your next dose (trough level) or at a particular time of day.

What do the results mean?

Results are typically reported in micrograms per milliliter (μg/mL) or milligrams per liter (mg/L). The therapeutic reference range for barbital is generally between 1-5 μg/mL, though this may vary slightly between laboratories. Results below the therapeutic range may indicate that the dose is too low or that the patient is not taking the medication as prescribed. Results above the therapeutic range may suggest overdose or toxicity, which can cause symptoms such as severe drowsiness, slurred speech, impaired coordination, slow breathing, or even coma in extreme cases.

Reference range

Therapeutic: 2-10 mg/L; reference range is not established for individuals not receiving barbital therapyN/A

Specimen: serum

No special preparation required. Specimen should be collected prior to next scheduled dose for therapeutic monitoring.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Frequently asked questions

Do I need to fast before this test?
Typically, no fasting is required for a barbital blood test. However, always follow your doctor's specific instructions. Inform your healthcare provider about all medications, supplements, and vitamins you are taking, as some substances may affect the test results.
What are the side effects of barbital?
Common side effects include drowsiness, dizziness, headache, nausea, and mild confusion. More serious side effects may include severe sedation, difficulty breathing, skin rash, and unusual bleeding or bruising. Contact your doctor immediately if you experience any concerning symptoms.
How often do I need this test?
The frequency of testing depends on your individual situation. Your doctor may order the test regularly when you first start therapy, after any dose change, or if you experience symptoms of toxicity. Some patients may only need periodic monitoring.
What happens if my level is too high?
If your barbital level is above the therapeutic range, your doctor may reduce your dose or switch you to a different medication. In cases of significant overdose, you may need hospitalization for monitoring and supportive care, which may include breathing assistance and intravenous fluids.
Is barbital still commonly prescribed?
Barbital is considered a legacy medication and is less commonly prescribed today due to the availability of safer alternatives with fewer side effects and lower risk of dependence. However, it may still be used in specific clinical situations where other medications have not been effective.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy