Skip to content

Medical Laboratory Test: What to Expect and How to Understand Your Results

Published: August 9, 2026Updated: August 16, 2026

This test checks for barbiturate drugs in your saliva to monitor medication levels or detect substance use.

Quick summary

{"Uses a saliva sample to detect barbiturate medications","Helps doctors monitor proper medication dosing","May be used for drug screening in certain situations","The confirmatory method ensures accurate results","Avoid eating, drinking, or smoking before the test"}

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
73663-7
Short code
BARBSAL
Synonyms
Barbiturates Pnl Sal Cfm
Category
chemistry
Sample
serum
Container
Specialized oral fluid (saliva) collection device with integrated collection pad/foam swab and transport tube containing stabilizing buffer; Salivette or equivalent collection kit.
Units
N/A
Ref low
10
Ref high
50
Fasting
false
Population
adult
Sex
all
Age range
1–99 years
Method
confirm
CPT
80345
SNOMED
431396003
Specimen volume
Minimum 1 mL of oral fluid; device-specific collection volume per manufacturer instructions (typically saturating the collection device).
Stability
Oral fluid specimen stable for 24-48 hours at room temperature (15-25°C), up to 7 days refrigerated (2-8°C), and up to 14-30 days frozen (-20°C) in appropriate collection/transport container with preservative buffer. Avoid repeated freeze-thaw cycles.
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
24–72 hours
Order
routine

This is a laboratory test that helps your healthcare provider check how your body is working and look for signs of illness. The test measures specific substances in a sample taken from your body, and the findings guide decisions about your diagnosis, treatment, and follow-up care.

The Barbiturates Panel test looks for barbiturate drugs in your saliva (oral fluid). Barbiturates are prescription medications that slow down brain activity. They are used to treat conditions like seizures, sleep disorders, and anxiety. Examples include phenobarbital, pentobarbital, and secobarbital. The 'confirmatory' part means this test uses a highly accurate laboratory method to verify results.

The test is usually done by collecting a small sample, such as blood, urine, or a swab, at a clinic, hospital, or laboratory. A trained technician will guide you through each step, the collection typically takes only a few minutes, and you can usually return to your normal activities right afterward.

A healthcare provider will collect a saliva sample by placing a special swab or collection device in your mouth for a few minutes to absorb saliva. The sample is then sent to a laboratory for testing. The test uses advanced methods to identify and measure barbiturate levels in your saliva.

Your care team will give you specific instructions before your test. Depending on the type of test, you may need to fast for several hours, avoid certain foods, drinks, or medications, or drink extra water beforehand. Tell your provider about any medicines, supplements, or allergies you have, and plan to arrive on time.

Before the test, avoid eating, drinking (except water), chewing gum, or smoking for at least 10-30 minutes as directed by your healthcare provider. Inform your doctor about all medications, supplements, and herbal products you are taking, as some substances may affect the results. Follow any specific instructions given by your healthcare provider.

Your results show whether the measured values fall within the normal reference range for your age and overall health. Abnormal results do not always mean you have a serious condition, so your provider will review them with you, explain what they may indicate, and decide whether further testing or treatment is needed.

Your results will show whether barbiturates were detected in your saliva and possibly the amount present. If you are taking barbiturate medication as prescribed, the test helps ensure you are taking the correct dose. A positive result could indicate prescribed use, misuse, or exposure to barbiturates. Your doctor will interpret the results in the context of your medical history and current medications.

Reference range

Negative: Below the limit of quantitation (< cutoff threshold). Cutoff concentrations vary by laboratory and panel component (e.g., amobarbital, butabarbital, butalbital, pentobarbital, phenobarbital, secobarbital) typically ranging from 10-50 ng/mL.N/A

Specimen: serum

No special patient preparation is required. The patient should refrain from eating, drinking, or using oral hygiene products for at least 10 minutes prior to specimen collection to avoid contamination or dilution of oral fluid. Inform the patient about the collection procedure.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

This test is used to monitor patients taking barbiturate medications for therapeutic purposes, ensuring drug levels remain within the effective and safe range. It is also used in substance abuse testing programs, workplace drug screening, and forensic settings. The confirmatory method (typically gas chromatography-mass spectrometry or liquid chromatography-tandem mass spectrometry) provides highly specific and accurate results, reducing the chance of false positives from other substances.

Frequently asked questions

Will the test show if I took my medication as prescribed?
Yes, the test can detect barbiturates in your saliva, which reflects recent medication use. If you are taking barbiturates as prescribed, the results should be consistent with your dosage. Always take your medication exactly as your doctor prescribed.
How long do barbiturates stay in saliva?
Barbiturates can typically be detected in saliva for 1-5 days after use, depending on the specific drug, dosage, and individual factors like metabolism. Your doctor can provide more specific information based on your situation.
Can over-the-counter medications affect the results?
Some over-the-counter medications and supplements may potentially interfere with the test. It is important to inform your healthcare provider about all medications, vitamins, and herbal supplements you are taking before the test.
Is this test painful?
No, the saliva test is simple and painless. A swab is placed in your mouth to collect saliva, which takes only a few minutes and causes no discomfort.
  1. 1
  2. 2
  3. 3

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy