Medical Laboratory Test: What to Expect and How to Understand Your Results
This test checks for barbiturate drugs in your saliva to monitor medication levels or detect substance use.
{"Uses a saliva sample to detect barbiturate medications","Helps doctors monitor proper medication dosing","May be used for drug screening in certain situations","The confirmatory method ensures accurate results","Avoid eating, drinking, or smoking before the test"}
Key facts at a glance
- LOINC
- 73663-7
- Short code
- BARBSAL
- Synonyms
- Barbiturates Pnl Sal Cfm
- Category
- chemistry
- Sample
- serum
- Container
- Specialized oral fluid (saliva) collection device with integrated collection pad/foam swab and transport tube containing stabilizing buffer; Salivette or equivalent collection kit.
- Units
- N/A
- Ref low
- 10
- Ref high
- 50
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 1–99 years
- Method
- confirm
- CPT
- 80345
- SNOMED
- 431396003
- Specimen volume
- Minimum 1 mL of oral fluid; device-specific collection volume per manufacturer instructions (typically saturating the collection device).
- Stability
- Oral fluid specimen stable for 24-48 hours at room temperature (15-25°C), up to 7 days refrigerated (2-8°C), and up to 14-30 days frozen (-20°C) in appropriate collection/transport container with preservative buffer. Avoid repeated freeze-thaw cycles.
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 24–72 hours
- Order
- routine
This is a laboratory test that helps your healthcare provider check how your body is working and look for signs of illness. The test measures specific substances in a sample taken from your body, and the findings guide decisions about your diagnosis, treatment, and follow-up care.
The Barbiturates Panel test looks for barbiturate drugs in your saliva (oral fluid). Barbiturates are prescription medications that slow down brain activity. They are used to treat conditions like seizures, sleep disorders, and anxiety. Examples include phenobarbital, pentobarbital, and secobarbital. The 'confirmatory' part means this test uses a highly accurate laboratory method to verify results.
The test is usually done by collecting a small sample, such as blood, urine, or a swab, at a clinic, hospital, or laboratory. A trained technician will guide you through each step, the collection typically takes only a few minutes, and you can usually return to your normal activities right afterward.
A healthcare provider will collect a saliva sample by placing a special swab or collection device in your mouth for a few minutes to absorb saliva. The sample is then sent to a laboratory for testing. The test uses advanced methods to identify and measure barbiturate levels in your saliva.
Your care team will give you specific instructions before your test. Depending on the type of test, you may need to fast for several hours, avoid certain foods, drinks, or medications, or drink extra water beforehand. Tell your provider about any medicines, supplements, or allergies you have, and plan to arrive on time.
Before the test, avoid eating, drinking (except water), chewing gum, or smoking for at least 10-30 minutes as directed by your healthcare provider. Inform your doctor about all medications, supplements, and herbal products you are taking, as some substances may affect the results. Follow any specific instructions given by your healthcare provider.
Your results show whether the measured values fall within the normal reference range for your age and overall health. Abnormal results do not always mean you have a serious condition, so your provider will review them with you, explain what they may indicate, and decide whether further testing or treatment is needed.
Your results will show whether barbiturates were detected in your saliva and possibly the amount present. If you are taking barbiturate medication as prescribed, the test helps ensure you are taking the correct dose. A positive result could indicate prescribed use, misuse, or exposure to barbiturates. Your doctor will interpret the results in the context of your medical history and current medications.
Reference range
Negative: Below the limit of quantitation (< cutoff threshold). Cutoff concentrations vary by laboratory and panel component (e.g., amobarbital, butabarbital, butalbital, pentobarbital, phenobarbital, secobarbital) typically ranging from 10-50 ng/mL.N/A
No special patient preparation is required. The patient should refrain from eating, drinking, or using oral hygiene products for at least 10 minutes prior to specimen collection to avoid contamination or dilution of oral fluid. Inform the patient about the collection procedure.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
This test is used to monitor patients taking barbiturate medications for therapeutic purposes, ensuring drug levels remain within the effective and safe range. It is also used in substance abuse testing programs, workplace drug screening, and forensic settings. The confirmatory method (typically gas chromatography-mass spectrometry or liquid chromatography-tandem mass spectrometry) provides highly specific and accurate results, reducing the chance of false positives from other substances.
Frequently asked questions
Will the test show if I took my medication as prescribed?
How long do barbiturates stay in saliva?
Can over-the-counter medications affect the results?
Is this test painful?
Sources
- 1
- 2
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy