Complete Blood Count (CBC): What This Common Blood Test Measures and Why Your Doctor May Order It
A blood test that measures the amount of acid or base in your blood to help evaluate your acid-base balance.
{"Base excess measures whether your blood is too acidic or too alkaline","It helps doctors diagnose and monitor conditions affecting blood pH","The test is performed on blood drawn from a central venous catheter","Normal values typically range from -2 to +2 mEq/L","Abnormal results may indicate kidney disease, lung problems, or metabolic disorders"}
Key facts at a glance
- LOINC
- 97546-6
- Short code
- Base excess BldCV Calc-sCnc
- Synonyms
- Base excess BldCV Calc-sCnc
- Category
- chemistry
- Sample
- whole-blood
- Container
- Lavender-top (EDTA)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- calculated
- Specimen volume
- 3 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
A complete blood count (CBC) is one of the most frequently ordered blood tests. It measures the cells that make up your blood, including red blood cells, white blood cells, and platelets, giving your care team a broad picture of your overall health and helping detect a wide range of conditions.
Base excess (BE) is a calculation that measures the amount of excess acid or base in your blood. It tells your doctor how much strong acid would be needed to bring your blood back to a normal pH of 7.4. A positive base excess means there is too much base (alkaline) in your blood, while a negative base excess indicates too much acid.
Your doctor may order a CBC as part of a routine checkup, to look into symptoms such as fatigue, weakness, fever, or unusual bruising, to help diagnose problems like anemia or infection, or to monitor how an ongoing illness or treatment is affecting your blood and your body over time.
This test is part of a blood gas analysis and is used to evaluate your acid-base balance. It helps doctors determine if you have metabolic acidosis (too acidic), metabolic alkalosis (too alkaline), or respiratory disorders affecting your blood pH. It is commonly ordered for patients in critical care, those with kidney disease, severe infections, or breathing difficulties.
A small blood sample is usually drawn from a vein in your arm, often at the inside of the elbow. A technician cleans the site, places a band around your upper arm, inserts a thin needle, and collects the blood into a tube. The process takes only a few minutes, and for children a fingerstick or heelstick may be used instead.
The test requires a blood sample drawn from a central venous catheter (a tube placed in a large vein, typically in the neck, chest, or groin). The blood is then analyzed in a laboratory using specialized equipment to calculate the base excess value. No fasting or special preparation is typically required for this test.
Your report will list values for red blood cells, white blood cells, platelets, hemoglobin, and hematocrit, often shown next to a reference range. Results slightly outside the range are not always cause for concern, and no single number tells the whole story. Review your results with your doctor, who will interpret them alongside your symptoms, history, and other tests.
Normal base excess values typically range from -2 to +2 mEq/L. A result outside this range may indicate an underlying health problem that requires further evaluation and treatment.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Base excess is clinically significant because it helps differentiate between respiratory and metabolic causes of acid-base imbalance. A low base excess (negative value) may indicate metabolic acidosis, which can be caused by kidney failure, diabetic ketoacidosis, lactic acidosis, or severe diarrhea. A high base excess (positive value) may indicate metabolic alkalosis, which can result from prolonged vomiting, diuretic use, or certain hormone disorders. This test is particularly valuable in critical care settings for monitoring patients on ventilators and those with severe illness.
Frequently asked questions
Do I need to fast before this test?
Is the test painful?
What can cause abnormal base excess?
How is this test different from blood pH testing?
Sources
- 1
- 2
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy