Bburgdor34kdiggcsfqlib

What is this test?

This test looks for IgG (immunoglobulin G) antibodies against Borrelia burgdorferi, the bacteria that causes Lyme disease, in your cerebrospinal fluid (CSF). Cerebrospinal fluid is the clear fluid that surrounds your brain and spinal cord. The test uses a method called immunoblot (also known as Western blot) to detect antibodies that target a specific 34kD protein from the Lyme disease bacteria.

Why is this test performed?

This test is primarily used to diagnose Lyme neuroborreliosis, which occurs when Lyme disease affects the nervous system. Symptoms of neurological Lyme disease may include facial palsy (drooping), meningitis, nerve pain, limb weakness, and cognitive difficulties. By detecting specific antibodies in the CSF, doctors can determine if the nervous system has been infected with Lyme disease bacteria.

How is the sample collected?

Cerebrospinal fluid is collected through a procedure called a lumbar puncture (spinal tap). During this procedure, a healthcare provider inserts a thin needle into the lower back to withdraw a small amount of CSF from the space around the spinal cord. The sample is then sent to a laboratory for analysis.

What do the results mean?

A positive result indicates that IgG antibodies against the 34kD protein of Borrelia burgdorferi were detected in your cerebrospinal fluid. This suggests that your immune system has produced a specific response to Lyme disease bacteria, and that the infection may be affecting or has affected your nervous system. A negative result means no antibodies were detected, but this does not completely rule out Lyme disease, especially if the infection is very recent. Your doctor will interpret these results alongside your symptoms, medical history, and other test results.