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Bburgdorc6abseracnc

Published: August 9, 2026Updated: August 15, 2026

A blood test that checks for antibodies against Borrelia burgdorferi, the bacterium that causes Lyme disease.

Quick summary

{"Detects immune response to Lyme disease-causing bacteria","Used to diagnose Lyme disease infection","Blood sample required, taken from a vein in your arm","Results help determine if you have been exposed to Lyme disease","Results are typically available within a few days"}

Medically reviewed by WellAlly Editorial TeamLast reviewed August 15, 2026Editorial policy

Key facts at a glance

LOINC
43075-1
Short code
LYC6
Synonyms
B burgdor C6 Ab Ser-aCnc
Category
chemistry
Sample
serum
Container
Serum separator tube (SST) or red-top vacutainer tube
Units
N/A
Ref low
5
Ref high
9
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
Enzyme Immunoassay (EIA) / Chemiluminescent Immunoassay (CLIA) for detection of antibodies against the C6 peptide of Borrelia burgdorferi
CPT
86618
SNOMED
416684001
Specimen volume
1-2 mL of serum (minimum 0.5 mL)
Stability
Stable for 7 days at 2-8°C; stable for 30 days at -20°C or below for longer storage
Hemolysis max
500
Lipemia max
500
Icterus max
500
TAT
24–72 hours
Order
routine

What is this test?

The Borrelia burgdorferi C6 Antibody test is a blood test that looks for specific antibodies in your blood that your immune system produces in response to the bacterium Borrelia burgdorferi, which causes Lyme disease. The C6 test is considered a highly specific test for Lyme disease detection.

Why is this test performed?

This test is primarily used to help diagnose Lyme disease, especially in patients who have symptoms suggestive of the infection. Symptoms may include a characteristic 'bull's-eye' rash (erythema migrans), fever, headache, fatigue, and joint or muscle pain. It is often ordered when a patient has been bitten by a tick or has been in areas where Lyme disease is common.

How is the test done?

A healthcare professional will draw a small sample of blood from a vein in your arm using a needle. The blood sample is then sent to a laboratory for analysis. The test measures the presence and level of C6 antibodies in your serum.

What do the results mean?

Results are typically reported as positive or negative. A positive result indicates that antibodies to Borrelia burgdorferi were detected, suggesting a current or past infection. A negative result means no antibodies were detected, which could mean you do not have Lyme disease or that the infection is very early (before antibodies have developed). Your healthcare provider will interpret the results in context with your symptoms and exposure history.

Are there any risks?

The risks associated with this blood test are minimal and include slight pain or bruising at the puncture site, lightheadedness, and in rare cases, infection. These risks are generally minor and resolve quickly.

Reference range

Negative: <5 U/mL; Equivocal: 5-9 U/mL; Positive: ≥10 U/mL (reference ranges may vary by laboratory and assay manufacturer)N/A

Specimen: serum

No fasting required. Patients should inform their healthcare provider of any recent antibiotic use, tick exposure, travel history, and vaccination status prior to testing.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Frequently asked questions

Do I need to fast before this test?
No, you do not need to fast before this test. You can eat and drink normally before the blood draw.
How long does it take to get results?
Results are typically available within 1-5 days, depending on the laboratory. Your healthcare provider will contact you with the results or discuss them at your follow-up appointment.
Can this test detect early Lyme disease?
In the early stages of Lyme disease, antibodies may not yet be detectable. If you have symptoms but test negative early on, your doctor may recommend repeat testing after a few weeks.
Will a positive result mean I have active Lyme disease?
A positive result indicates exposure to the Lyme disease bacteria, but does not necessarily mean you have active disease. Your healthcare provider will consider your symptoms, physical findings, and test results to determine if treatment is needed.
Is the test painful?
You may feel a brief sting or pinch when the needle is inserted to draw blood. Most people find the discomfort minimal and short-lived.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 15, 2026. · Read our editorial policy