Understanding Your Laboratory Test: A Patient Guide to Medical Testing and What It Means for Your Health
This test detects IgA antibodies against Borrelia burgdorferi, the bacterium that causes Lyme disease, in your blood.
{"Detects IgA antibodies to Lyme disease bacteria in serum","Used to help diagnose Lyme disease, especially in later stages","A positive result suggests current or past infection","Results should be interpreted with other clinical findings","Performed on a blood serum sample"}
Key facts at a glance
- LOINC
- 22124-2
- Short code
- LYMEIGA
- Synonyms
- B burgdor IgA Ser Ql
- Category
- chemistry
- Sample
- serum
- Container
- Serum separator tube (SST) or red-top vacutainer tube
- Units
- N/A
- Ref low
- 2
- Ref high
- 4
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- Enzyme-linked immunosorbent assay (ELISA) or Immunofluorescence Assay (IFA) for detection of IgA antibodies against Borrelia burgdorferi
- CPT
- 86618
- SNOMED
- 415693003
- Specimen volume
- 1-2 mL of serum
- Stability
- Room temperature: 8 hours. Refrigerated (2-8°C): 7 days. Frozen (-20°C or below): 30 days. Avoid repeated freeze-thaw cycles.
- Hemolysis max
- 100
- Lipemia max
- 100
- Icterus max
- 50
- TAT
- 24–72 hours
- Order
- routine
This test is a laboratory procedure in which a sample, such as blood, urine, or tissue, is collected and analyzed to help your healthcare provider assess your overall health, screen for disease, or monitor a medical condition you may already have.
The Borrelia burgdorferi IgA Antibody test is a blood test that looks for IgA antibodies against the bacteria that cause Lyme disease. IgA antibodies are one of the first types of antibodies your immune system produces in response to an infection. This test determines whether these specific antibodies are present in your bloodstream.
Your doctor may order this test to confirm or rule out a suspected illness, investigate symptoms you have been experiencing, check how well a particular organ is functioning, or track how effectively a treatment you are receiving is working over time.
This test is primarily used to help diagnose Lyme disease, especially in its early to mid-stages. It may be ordered when a patient has symptoms suggestive of Lyme disease, such as the characteristic 'bull's-eye' rash (erythema migrans), fever, headache, fatigue, or joint pain, particularly if there is a history of potential tick exposure.
The test is usually performed by a trained healthcare professional who collects the required sample, most often through a simple blood draw from a vein in your arm, and the sample is then sent to a laboratory where it is carefully examined and measured.
A healthcare professional will draw a small sample of blood from a vein in your arm. This blood sample is then sent to a laboratory where it is tested for the presence of IgA antibodies against Borrelia burgdorferi. The test looks for whether these antibodies are 'present' or 'not present' in your serum.
Your results are compared with established reference ranges, and values that fall outside the normal range may point to infection, inflammation, organ dysfunction, or another condition, but only your healthcare provider can interpret them correctly in the context of your health.
A 'Positive' result means that IgA antibodies to Borrelia burgdorferi were detected in your blood, suggesting that you may have been infected with the Lyme disease bacteria. A 'Negative' result means no IgA antibodies were detected. However, it's important to note that antibodies may not appear immediately after infection, so testing too early may give a false negative. Your healthcare provider will interpret these results in combination with your symptoms, exposure history, and possibly other test results.
Reference range
Negative: No detectable IgA antibodies to Borrelia burgdorferi. Positive: Presence of IgA antibodies, suggestive of current or recent infection. Equivocal/Borderline results should be confirmed by Western blot or repeat testing in 2-4 weeks.N/A
No special preparation required. Patients should inform their healthcare provider of any recent antibiotic use, tick exposure history, travel to endemic areas, and current symptoms suggestive of Lyme disease (erythema migrans, arthralgia, neurological symptoms).
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
The presence of IgA antibodies to Borrelia burgdorferi can aid in the diagnosis of Lyme disease, particularly when symptoms have been present for several weeks. IgA antibodies typically appear within 2-4 weeks after a tick bite and may persist for months. This test is often used alongside other Lyme disease tests (such as IgG antibody tests) for a more complete diagnostic picture. However, cross-reactivity with other conditions is possible, so clinical correlation is essential.
Frequently asked questions
Do I need to fast before this test?
How long does it take to get results?
Can this test tell me if I have Lyme disease right now?
Is the test painful?
What should I do if my test is positive?
Sources
- 1
- 2
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 15, 2026. · Read our editorial policy