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Understanding Your Laboratory Test: A Patient Guide to Medical Testing and What It Means for Your Health

Published: August 9, 2026Updated: August 15, 2026

This test detects IgA antibodies against Borrelia burgdorferi, the bacterium that causes Lyme disease, in your blood.

Quick summary

{"Detects IgA antibodies to Lyme disease bacteria in serum","Used to help diagnose Lyme disease, especially in later stages","A positive result suggests current or past infection","Results should be interpreted with other clinical findings","Performed on a blood serum sample"}

Medically reviewed by WellAlly Editorial TeamLast reviewed August 15, 2026Editorial policy

Key facts at a glance

LOINC
22124-2
Short code
LYMEIGA
Synonyms
B burgdor IgA Ser Ql
Category
chemistry
Sample
serum
Container
Serum separator tube (SST) or red-top vacutainer tube
Units
N/A
Ref low
2
Ref high
4
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
Enzyme-linked immunosorbent assay (ELISA) or Immunofluorescence Assay (IFA) for detection of IgA antibodies against Borrelia burgdorferi
CPT
86618
SNOMED
415693003
Specimen volume
1-2 mL of serum
Stability
Room temperature: 8 hours. Refrigerated (2-8°C): 7 days. Frozen (-20°C or below): 30 days. Avoid repeated freeze-thaw cycles.
Hemolysis max
100
Lipemia max
100
Icterus max
50
TAT
24–72 hours
Order
routine

This test is a laboratory procedure in which a sample, such as blood, urine, or tissue, is collected and analyzed to help your healthcare provider assess your overall health, screen for disease, or monitor a medical condition you may already have.

The Borrelia burgdorferi IgA Antibody test is a blood test that looks for IgA antibodies against the bacteria that cause Lyme disease. IgA antibodies are one of the first types of antibodies your immune system produces in response to an infection. This test determines whether these specific antibodies are present in your bloodstream.

Your doctor may order this test to confirm or rule out a suspected illness, investigate symptoms you have been experiencing, check how well a particular organ is functioning, or track how effectively a treatment you are receiving is working over time.

This test is primarily used to help diagnose Lyme disease, especially in its early to mid-stages. It may be ordered when a patient has symptoms suggestive of Lyme disease, such as the characteristic 'bull's-eye' rash (erythema migrans), fever, headache, fatigue, or joint pain, particularly if there is a history of potential tick exposure.

The test is usually performed by a trained healthcare professional who collects the required sample, most often through a simple blood draw from a vein in your arm, and the sample is then sent to a laboratory where it is carefully examined and measured.

A healthcare professional will draw a small sample of blood from a vein in your arm. This blood sample is then sent to a laboratory where it is tested for the presence of IgA antibodies against Borrelia burgdorferi. The test looks for whether these antibodies are 'present' or 'not present' in your serum.

Your results are compared with established reference ranges, and values that fall outside the normal range may point to infection, inflammation, organ dysfunction, or another condition, but only your healthcare provider can interpret them correctly in the context of your health.

A 'Positive' result means that IgA antibodies to Borrelia burgdorferi were detected in your blood, suggesting that you may have been infected with the Lyme disease bacteria. A 'Negative' result means no IgA antibodies were detected. However, it's important to note that antibodies may not appear immediately after infection, so testing too early may give a false negative. Your healthcare provider will interpret these results in combination with your symptoms, exposure history, and possibly other test results.

Reference range

Negative: No detectable IgA antibodies to Borrelia burgdorferi. Positive: Presence of IgA antibodies, suggestive of current or recent infection. Equivocal/Borderline results should be confirmed by Western blot or repeat testing in 2-4 weeks.N/A

Specimen: serum

No special preparation required. Patients should inform their healthcare provider of any recent antibiotic use, tick exposure history, travel to endemic areas, and current symptoms suggestive of Lyme disease (erythema migrans, arthralgia, neurological symptoms).

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

The presence of IgA antibodies to Borrelia burgdorferi can aid in the diagnosis of Lyme disease, particularly when symptoms have been present for several weeks. IgA antibodies typically appear within 2-4 weeks after a tick bite and may persist for months. This test is often used alongside other Lyme disease tests (such as IgG antibody tests) for a more complete diagnostic picture. However, cross-reactivity with other conditions is possible, so clinical correlation is essential.

Frequently asked questions

Do I need to fast before this test?
No, fasting is not typically required for this blood test. You can eat and drink normally before having your blood drawn.
How long does it take to get results?
Results are usually available within a few days to a week, depending on the laboratory. Your healthcare provider will inform you when results are ready.
Can this test tell me if I have Lyme disease right now?
This test detects antibodies, not the bacteria itself. A positive result indicates that your immune system has been exposed to the bacteria at some point. Your doctor will consider this along with your symptoms, physical findings, and potentially other test results to determine if you have an active infection.
Is the test painful?
You may feel a brief pinch or mild discomfort when the blood is drawn, but the procedure is generally well-tolerated. The discomfort is temporary and subsides quickly.
What should I do if my test is positive?
If your test is positive, it is important to discuss the results with your healthcare provider. They will evaluate your overall clinical picture and determine if treatment with antibiotics is necessary. Lyme disease is typically treated successfully with antibiotics, especially when caught early.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 15, 2026. · Read our editorial policy