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Bburgdoriggigmserrto

Published: August 9, 2026Updated: August 16, 2026

A blood test that detects antibodies against Borrelia burgdorferi, the bacterium that causes Lyme disease, transmitted by tick bites.

Quick summary

{"Detects IgM antibodies (early infection) and IgG antibodies (later infection)","Used to diagnose Lyme disease after a tick bite or characteristic symptoms","Results are reported as a ratio indicating positive or negative for each antibody type","Testing may require confirmation if initial results are positive or equivocal","Early detection and treatment with antibiotics is important for recovery"}

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
41279-1
Short code
LYMEAB
Synonyms
B burgdor IgG/IgM Ser-Rto
Category
chemistry
Sample
serum
Container
Serum separator tube (SST), red-top tube, or gold-top tube
Units
N/A
Ref low
0
Ref high
0.89
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
Two-tier testing algorithm: Initial enzyme immunoassay (EIA) or immunofluorescence assay (IFA) screening, followed by confirmatory Western blot or modified Western blot for IgG and IgM antibodies. Ratio represents a calculated index value combining IgG and IgM antibody responses.
CPT
86618
SNOMED
387713003
Specimen volume
1.0-2.0 mL of serum (minimum 0.5 mL)
Stability
Room temperature: 8 hours; Refrigerated (2-8°C): 7 days; Frozen (-20°C or below): 30 days. Avoid repeated freeze-thaw cycles.
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
24–72 hours
Order
routine

What is this test?

The Borrelia burgdorferi IgG/IgM Antibody test is a blood test that looks for antibodies your body produces in response to infection with the bacterium Borrelia burgdorferi, which causes Lyme disease. This bacterium is transmitted through the bite of infected blacklegged ticks (deer ticks). The test measures two types of antibodies: IgM (immunoglobulin M), which appear early in infection, and IgG (immunoglobulin G), which develop later.

Why is this test performed?

This test is performed when you have symptoms suggestive of Lyme disease, especially if you have been bitten by a tick or have spent time in areas where Lyme disease is common. Early symptoms may include a characteristic "bull's-eye" rash (erythema migrans), fever, headache, fatigue, and muscle aches. Later symptoms can include joint pain, neurological problems, and heart involvement. The test helps confirm whether your symptoms are due to Lyme disease.

What do the results mean?

Results are typically reported as a ratio or as positive/negative for IgM and IgG antibodies. A positive IgM result suggests early infection, as IgM antibodies usually appear within 1-2 weeks after a tick bite. A positive IgG result indicates a later stage of infection, as IgG antibodies typically develop 4-6 weeks after infection. In some cases, both IgM and IgG may be positive. Your healthcare provider will interpret these results along with your symptoms and exposure history. Sometimes additional confirmatory testing (like Western blot) may be recommended.

How is the test done?

A blood sample is drawn from a vein in your arm. The sample is then sent to a laboratory for analysis. The test uses laboratory techniques to detect the presence of IgM and IgG antibodies against Borrelia burgdorferi. You do not need to fast or make any special preparations before this test.

Reference range

Negative: <0.90 ratio; Equivocal: 0.90-1.09 ratio; Positive: ≥1.10 ratio. Reference ranges vary by performing laboratory and assay manufacturer.N/A

Specimen: serum

No special patient preparation required. Fasting is not necessary. Patients should inform their healthcare provider about recent antibiotic use, current symptoms, and history of tick exposure or tick bite.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Frequently asked questions

How soon after a tick bite can this test detect Lyme disease?
IgM antibodies usually become detectable within 1-2 weeks after infection, while IgG antibodies typically appear 4-6 weeks after the tick bite. If you are tested too early (within the first week), you may get a false-negative result even if you are infected.
Do I need to do anything special to prepare for this test?
No special preparation is needed. You do not need to fast before the test. Simply inform your healthcare provider about any medications or supplements you are taking, as these generally do not affect the test results.
What does a positive result mean?
A positive result indicates that you have antibodies to Borrelia burgdorferi, suggesting you have been infected with the Lyme disease bacterium. Your healthcare provider will consider this along with your symptoms, medical history, and possible tick exposure to confirm the diagnosis and recommend appropriate treatment, which usually involves antibiotics.
Can I still have Lyme disease if the test is negative?
Yes, it is possible. During the early stage of infection, your body may not have produced enough antibodies to be detected. Additionally, some people with early Lyme disease may only have the characteristic rash without developing detectable antibodies yet. If your symptoms persist, your doctor may recommend repeat testing or additional evaluations.
Is this test used to check if treatment is working?
Generally, this test is not used to monitor treatment response. Antibody levels can remain elevated for months or even years after successful treatment. Your doctor will primarily assess whether your symptoms are improving after antibiotic therapy rather than relying on follow-up blood tests.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy