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IgG and IgM Antibody Blood Test: What You Need to Know

Published: August 9, 2026Updated: August 15, 2026

A blood test that detects antibodies against Brucella canis bacteria to help diagnose infection from dog contact.

Quick summary

{"This test checks for IgG and IgM antibodies against Brucella canis bacteria","IgM indicates recent or acute infection; IgG suggests past or ongoing infection","The test helps diagnose brucellosis in people exposed to infected dogs","Positive results may require follow-up testing and treatment"}

Medically reviewed by WellAlly Editorial TeamLast reviewed August 15, 2026Editorial policy

Key facts at a glance

LOINC
44077-6
Short code
BRUCIGM
Synonyms
B canis IgG+IgM Ser-Imp
Category
chemistry
Sample
serum
Container
Serum separator tube (SST) or red-top vacutainer tube
Units
N/A
Ref low
0
Ref high
1
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
Enzyme Immunoassay (EIA) or Immunofluorescence Assay (IFA); serum agglutination test (SAT) for confirmation
CPT
86622
SNOMED
38763004
Specimen volume
1-2 mL of serum (minimum 0.5 mL)
Stability
Serum stable for 7 days at 2-8°C; for prolonged storage, freeze at -20°C or below for up to 6 months. Avoid repeated freeze-thaw cycles.
Hemolysis max
100
Lipemia max
100
Icterus max
50
TAT
24–72 hours
Order
routine

This test measures two important antibodies in your blood, immunoglobulin G (IgG) and immunoglobulin M (IgM). Antibodies are proteins your immune system makes to help fight infections, and measuring them can give your doctor valuable information about your health.

The Brucella canis IgG and IgM test is a blood test that detects whether your immune system has produced antibodies against Brucella canis, a bacterium that can spread from dogs to humans. This test helps doctors determine if you have a current or past infection with this bacterium.

IgM is usually the first antibody your body produces when it meets a new infection, so higher levels may suggest a recent or current infection. IgG develops later and often stays in your blood for years, which can point to a past infection or long-lasting immunity.

IgM antibodies are produced first during an infection, usually within 1-2 weeks of exposure. Their presence typically indicates a recent or acute infection. IgG antibodies develop later, usually within 2-4 weeks, and provide long-term immunity. Detecting IgG may indicate a past infection or an ongoing chronic infection.

Your doctor may order this test to find out whether you have a current, recent, or past infection, to check how well your immune system is responding, or to see whether you have developed immunity after an infection or vaccination.

Your doctor may order this test if you have symptoms of brucellosis (such as fever, fatigue, joint pain, or muscle aches) and have recently been exposed to dogs, especially dogs from shelters, breeding facilities, or areas with known Brucella canis outbreaks. Veterinarians, dog breeders, and pet store workers are at higher risk.

A health care professional will draw a small sample of blood from a vein in your arm, usually on the inside of your elbow. The sample is then sent to a laboratory, where specialists measure the amount of IgG and IgM antibodies it contains.

A healthcare professional will draw a blood sample from a vein in your arm. The blood is then sent to a laboratory to test for the presence of IgG and IgM antibodies against Brucella canis.

Your results will show whether IgG or IgM was detected in your blood. Higher IgM levels may suggest a recent infection, while IgG without IgM often means you were exposed in the past. Your doctor will explain your specific values and whether any follow-up testing or treatment is needed.

Results are typically reported as positive or negative for IgG and IgM. A positive IgM result suggests recent infection. A positive IgG result may indicate past exposure or ongoing infection. Your doctor will interpret these results together with your symptoms and exposure history to make a diagnosis.

Reference range

Negative: IgG <1:80, IgM <1:20 (by standard tube agglutination); Titers vary by methodology. Positive IgG and/or IgM indicates exposure or active infection.N/A

Specimen: serum

No special patient preparation required. Fasting is not necessary for serological testing.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Brucella canis is a zoonotic bacterium that causes brucellosis in humans. While less common than other Brucella species, it can be transmitted through contact with infected dogs, particularly their bodily fluids, aborted fetuses, or contaminated environments. Symptoms in humans may include fever, sweats, fatigue, joint pain, and lymphadenopathy. In rare cases, it can lead to complications affecting the heart, liver, or nervous system. Early detection through antibody testing is important for timely treatment with antibiotics.

Frequently asked questions

Is Brucella canis infection serious?
While often treatable with antibiotics, Brucella canis infection can become chronic if not treated promptly. Some people may experience recurring symptoms or complications affecting the heart, liver, or joints. Early diagnosis and treatment are important for better outcomes.
How is Brucella canis spread from dogs to humans?
Humans can become infected through contact with infected dog bodily fluids, including blood, urine, vaginal discharge, or aborted fetal material. Breeding dogs, especially those in shelters or breeding operations, are more likely to carry the bacteria. Casual pet ownership carries lower risk, but general hygiene practices are recommended.
Do I need to test my dog for Brucella canis?
If your dog shows symptoms or you are concerned about exposure, consult your veterinarian. Testing dogs typically involves different methods than human testing. Keeping your dog healthy and following veterinary recommendations is important.
What happens if my test is positive?
If your test is positive, your doctor will discuss treatment options, which usually involve a course of antibiotics. They may also recommend testing household members or others who may have been exposed. Following your doctor's instructions carefully is important for complete recovery.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 15, 2026. · Read our editorial policy