IgG and IgM Antibody Blood Test: What You Need to Know
A blood test that detects antibodies against Brucella canis bacteria to help diagnose infection from dog contact.
{"This test checks for IgG and IgM antibodies against Brucella canis bacteria","IgM indicates recent or acute infection; IgG suggests past or ongoing infection","The test helps diagnose brucellosis in people exposed to infected dogs","Positive results may require follow-up testing and treatment"}
Key facts at a glance
- LOINC
- 44077-6
- Short code
- BRUCIGM
- Synonyms
- B canis IgG+IgM Ser-Imp
- Category
- chemistry
- Sample
- serum
- Container
- Serum separator tube (SST) or red-top vacutainer tube
- Units
- N/A
- Ref low
- 0
- Ref high
- 1
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- Enzyme Immunoassay (EIA) or Immunofluorescence Assay (IFA); serum agglutination test (SAT) for confirmation
- CPT
- 86622
- SNOMED
- 38763004
- Specimen volume
- 1-2 mL of serum (minimum 0.5 mL)
- Stability
- Serum stable for 7 days at 2-8°C; for prolonged storage, freeze at -20°C or below for up to 6 months. Avoid repeated freeze-thaw cycles.
- Hemolysis max
- 100
- Lipemia max
- 100
- Icterus max
- 50
- TAT
- 24–72 hours
- Order
- routine
This test measures two important antibodies in your blood, immunoglobulin G (IgG) and immunoglobulin M (IgM). Antibodies are proteins your immune system makes to help fight infections, and measuring them can give your doctor valuable information about your health.
The Brucella canis IgG and IgM test is a blood test that detects whether your immune system has produced antibodies against Brucella canis, a bacterium that can spread from dogs to humans. This test helps doctors determine if you have a current or past infection with this bacterium.
IgM is usually the first antibody your body produces when it meets a new infection, so higher levels may suggest a recent or current infection. IgG develops later and often stays in your blood for years, which can point to a past infection or long-lasting immunity.
IgM antibodies are produced first during an infection, usually within 1-2 weeks of exposure. Their presence typically indicates a recent or acute infection. IgG antibodies develop later, usually within 2-4 weeks, and provide long-term immunity. Detecting IgG may indicate a past infection or an ongoing chronic infection.
Your doctor may order this test to find out whether you have a current, recent, or past infection, to check how well your immune system is responding, or to see whether you have developed immunity after an infection or vaccination.
Your doctor may order this test if you have symptoms of brucellosis (such as fever, fatigue, joint pain, or muscle aches) and have recently been exposed to dogs, especially dogs from shelters, breeding facilities, or areas with known Brucella canis outbreaks. Veterinarians, dog breeders, and pet store workers are at higher risk.
A health care professional will draw a small sample of blood from a vein in your arm, usually on the inside of your elbow. The sample is then sent to a laboratory, where specialists measure the amount of IgG and IgM antibodies it contains.
A healthcare professional will draw a blood sample from a vein in your arm. The blood is then sent to a laboratory to test for the presence of IgG and IgM antibodies against Brucella canis.
Your results will show whether IgG or IgM was detected in your blood. Higher IgM levels may suggest a recent infection, while IgG without IgM often means you were exposed in the past. Your doctor will explain your specific values and whether any follow-up testing or treatment is needed.
Results are typically reported as positive or negative for IgG and IgM. A positive IgM result suggests recent infection. A positive IgG result may indicate past exposure or ongoing infection. Your doctor will interpret these results together with your symptoms and exposure history to make a diagnosis.
Reference range
Negative: IgG <1:80, IgM <1:20 (by standard tube agglutination); Titers vary by methodology. Positive IgG and/or IgM indicates exposure or active infection.N/A
No special patient preparation required. Fasting is not necessary for serological testing.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Brucella canis is a zoonotic bacterium that causes brucellosis in humans. While less common than other Brucella species, it can be transmitted through contact with infected dogs, particularly their bodily fluids, aborted fetuses, or contaminated environments. Symptoms in humans may include fever, sweats, fatigue, joint pain, and lymphadenopathy. In rare cases, it can lead to complications affecting the heart, liver, or nervous system. Early detection through antibody testing is important for timely treatment with antibiotics.
Frequently asked questions
Is Brucella canis infection serious?
How is Brucella canis spread from dogs to humans?
Do I need to test my dog for Brucella canis?
What happens if my test is positive?
Sources
- 1CDC - BrucellosisSource
- 2
- 3AVMA - Brucella canisSource
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 15, 2026. · Read our editorial policy