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This blood test measures the amount of DOCK8 protein on B cells using flow cytometry to help diagnose immune deficiency disorders.
{"Measures DOCK8 protein levels on B cells in your blood","Helps diagnose rare immune deficiencies like DOCK8 deficiency syndrome","A simple blood draw is all that's needed","Results help doctors understand why you may have frequent infections","Often used when patients have high IgE levels and recurrent infections"}
Key facts at a glance
- LOINC
- 96417-1
- Short code
- DOCK8-BCELL
- Synonyms
- B Cells DOCK8+/B Cells NFr Bld FC
- Category
- cardiac
- Sample
- whole-blood
- Container
- EDTA (lavender top) tube - Multiple tubes may be required for comprehensive immunophenotyping panel
- Units
- N/A
- Ref low
- 95
- Ref high
- 100
- Critical range
- 5 N/A – 10000 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 0–120 years
- Method
- flow-cytometry
- CPT
- 88188
- SNOMED
- 708198003
- Specimen volume
- 3-5 mL whole blood in EDTA tube, minimum 1 mL acceptable for limited panel
- Stability
- Room temperature: 24-48 hours. Do not refrigerate. Transport upright. Avoid extreme temperatures. Process within 24 hours for optimal results.
- Hemolysis max
- 50
- Lipemia max
- 100
- Icterus max
- 20
- TAT
- 48–168 hours
- Order
- routine
What is this test?
This test measures how much DOCK8 protein is present on the surface of B cells in your blood. B cells are a type of white blood cell that helps your body fight infections. DOCK8 is a special protein that helps these immune cells work properly. The test uses a technique called flow cytometry, which can count and examine different types of cells in detail.
How is the test done?
A healthcare professional will draw a small amount of blood from a vein in your arm. The blood sample is then sent to a laboratory where special dyes and lasers are used to detect DOCK8 protein on B cells. The entire process is similar to a routine blood test and takes just a few minutes.
Do I need to prepare for the test?
You do not need to fast or stop taking medications for this test. Simply follow your doctor's instructions and arrive at the lab at your scheduled time. The test is safe and has no special preparation requirements.
Reference range
Reference range: DOCK8+ B cells should represent >95% of total CD19+ B cells. Complete absence or severe reduction of DOCK8+ B cells (<5%) suggests DOCK8 deficiency. Interpretation should be correlated with clinical findings and additional immunological studies.N/A
No special preparation required. Test may be performed regardless of fasting status. Inform laboratory of any recent infections, immunosuppressive therapy, or immunizations as these may affect results.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings2
Frequently asked questions
Why does my doctor want this test?
Is this test painful?
How long does it take to get results?
What do abnormal results mean?
Sources
- 1
- 2
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy