Bcl6generearbldtfishimp
This test detects genetic changes in the BCL6 gene using FISH technology to help diagnose certain types of lymphoma.
{"BCL6 gene rearrangement test is used to diagnose lymphoma","The test uses FISH technology to detect genetic changes in blood or tissue samples","Results help doctors determine the best treatment approach","Abnormal results may indicate certain types of lymphoma, particularly diffuse large B-cell lymphoma and follicular lymphoma","The test is performed on a sample of blood or tissue from a biopsy"}
Key facts at a glance
- LOINC
- 78208-6
- Short code
- BCL6FISH
- Synonyms
- BCL6 gene Rear Bld/T FISH-Imp
- Category
- chemistry
- Sample
- whole-blood
- Container
- Lavender-top (EDTA) tube for whole blood; sterile container with tissue culture medium or RPMI for tissue specimens
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- Fluorescence In Situ Hybridization (FISH) with narrative interpretation
- CPT
- 88368
- SNOMED
- 450020006
- Specimen volume
- 3-5 mL whole blood; 1 cm³ fresh tissue or paraffin-embedded tissue block
- Stability
- Whole blood: Room temperature 24 hours; refrigerated (2-8°C) up to 72 hours. Tissue: Fresh tissue in RPMI stable 24-48 hours at 2-8°C; paraffin blocks stable indefinitely at room temperature
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 72–168 hours
- Order
- routine
What is this test?
The BCL6 gene rearrangement test is a specialized genetic test that uses Fluorescence In Situ Hybridization (FISH) technology to detect changes in the BCL6 gene. The BCL6 gene provides instructions for making a protein that helps regulate gene activity and is important for normal immune cell function. When this gene undergoes rearrangement (abnormal restructuring), it can contribute to the development of certain cancers, particularly lymphomas.
How is the test performed?
A healthcare provider will collect a sample either from your blood (via a vein in your arm) or from a tissue biopsy (usually from a lymph node or other affected tissue). The sample is then sent to a laboratory where technicians use FISH technology to examine the BCL6 gene. FISH uses fluorescent probes that bind to specific parts of the BCL6 gene, allowing scientists to see whether the gene has rearranged or changed under a special microscope.
Why is this test ordered?
Your doctor may order this test if you have symptoms suggesting lymphoma, such as enlarged lymph nodes, unexplained fever, night sweats, or weight loss. The test helps confirm a diagnosis and provides important information about the specific type of lymphoma, which guides treatment decisions.
Reference range
Negative for BCL6 gene rearrangement. Normal result: BCL6 rearrangement not detected in the specimen analyzed. Positive result indicates presence of BCL6 gene rearrangement, typically involving the 3q27 locus.N/A
No special patient preparation is required for this test. Patients should inform their healthcare provider about any recent blood transfusions, bone marrow transplantation, or ongoing chemotherapy, as these may affect results.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Frequently asked questions
Do I need to fast before this test?
How long does it take to get results?
Is the test painful?
What do abnormal results mean?
Will I need additional tests?
Sources
- 1
- 2
- 3LOINC Code ReferenceSource
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy