Prostate-Specific Antigen (PSA), Tissue
This test detects prostate-specific antigen in tissue, often to help determine whether a tumor or abnormal cells originated in the prostate.
["A positive tissue PSA result can support a prostate origin for certain tumors, but it must be interpreted with the other biopsy findings."]
Key facts at a glance
- LOINC
- 107338-6
- Short code
- BC molec sub Tiss Prosigna
- Synonyms
- BC molec sub Tiss Prosigna
- Category
- liver
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 136
- Ref high
- 145
- Critical range
- 120 N/A – 160 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- prosigna
- CPT
- 84295
- SNOMED
- 110741000
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What is this test?
Prostate-specific antigen, or PSA, is a protein made by prostate cells. This test looks for PSA in a tissue sample and may be used to help identify prostate tissue or the prostate origin of cancer cells.
Why might I need this test?
A tissue PSA test may be ordered when cancer is found in a biopsy specimen and the pathologist needs to determine its likely tissue of origin. It may also be used in selected cases involving abnormal prostate tissue.
How is the test performed?
A laboratory specialist examines the tissue sample for PSA, often using a technique that highlights the presence of PSA in the cells. The result is reported as detected or not detected and is combined with the pathology findings.
How do I prepare for the test?
No special food, medicine, or fasting instructions are usually required for the laboratory analysis itself. If a biopsy or tissue removal is needed, your clinician will explain the procedure, local anesthetic use, and any preparation specific to that procedure.
Reference range
Adult: 136-145 mmol/LN/A
No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Short name
Tissue PSA
Frequently asked questions
Is tissue PSA the same as the blood PSA test?
Does a positive tissue PSA result mean I have prostate cancer?
Will I need a separate tissue sample for this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy