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Complete Blood Count (CBC): What You Need to Know

Published: August 9, 2026Updated: August 15, 2026

This test detects antibodies against Babesia divergens parasite in blood using immunofluorescence, used to diagnose tick-borne babesiosis infection.

Quick summary

{"Detects antibodies to Babesia divergens parasite transmitted by ticks","Used to confirm diagnosis of babesiosis when symptoms suggest infection","Results indicate whether your immune system has responded to the parasite","Positive result suggests current or recent infection","Negative result may mean no infection or test performed too early"}

Medically reviewed by WellAlly Editorial TeamLast reviewed August 15, 2026Editorial policy

Key facts at a glance

LOINC
22854-4
Short code
BABDV
Synonyms
B divergens Ab Ser Ql IF
Category
chemistry
Sample
serum
Container
Serum separator tube (SST) or red-top tube (no anticoagulant)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
≥ 0 years
Method
Immunofluorescence Assay (IFA)
CPT
86256
SNOMED
395140002
Specimen volume
1.0 mL serum (minimum 0.5 mL)
Stability
Stable for 7 days at 2-8°C. For prolonged storage, freeze at -20°C or below. Avoid repeated freeze-thaw cycles.
Hemolysis max
100
Lipemia max
100
Icterus max
50
TAT
24–72 hours
Order
routine

The complete blood count, or CBC, is one of the most common blood tests. It measures the different cells that make up your blood, including red blood cells, white blood cells, and platelets, and gives your healthcare provider a broad picture of your overall health.

The Babesia divergens antibody test is a blood test that detects whether your immune system has produced antibodies against Babesia divergens, a parasite that causes babesiosis. This parasite is transmitted through the bite of infected ticks, primarily the Ixodes ricinus tick found in Europe. The test uses a method called immunofluorescence to identify these specific antibodies in your blood sample.

This test is performed during routine checkups to screen for health problems, to help diagnose conditions such as anemia, infections, and blood disorders, to investigate symptoms like fatigue or fever, and to monitor how well treatments are working over time.

Your healthcare provider may order this test if you have symptoms of babesiosis, especially if you have been exposed to tick-infested areas or have a history of tick bites. Symptoms of babesiosis typically include fever, chills, sweats, headache, muscle aches, fatigue, and sometimes hemolytic anemia. This test helps confirm whether your symptoms are caused by Babesia divergens infection rather than other similar illnesses like malaria or Lyme disease.

A healthcare professional will draw a small sample of blood, usually from a vein in your arm, using a thin needle. The procedure takes only a few minutes and causes little more than a brief pinch, and the sample is then sent to a laboratory for analysis.

A healthcare professional will draw a small blood sample from a vein in your arm. This sample is then sent to a laboratory where technicians will use immunofluorescence techniques to detect Babesia divergens-specific antibodies. The test looks for the presence (positive) or absence (negative) of these antibodies in your serum.

Your results show whether your red blood cell, white blood cell, and platelet counts fall within normal ranges. Values outside these ranges may suggest anemia, infection, inflammation, or clotting problems, but your doctor will interpret them together with your symptoms, medications, and medical history before making any diagnosis.

A positive result indicates that antibodies to Babesia divergens were detected in your blood, suggesting that you have been infected with this parasite. However, antibodies can persist for months or even years after recovery, so a positive result may indicate either a current active infection or a past infection. A negative result means no antibodies were detected, which could mean you are not infected, or the test was performed too early in the infection before antibodies developed. Your healthcare provider will interpret your results in context with your symptoms and exposure history.

Reference range

Negative: No Babesia divergens antibodies detected. Positive: Antibodies to Babesia divergens detected at a titer of ≥1:64 (or as defined by the performing laboratory). Titers between 1:16 and 1:64 may indicate past exposure or early infection and should be interpreted in clinical context.N/A

Specimen: serum

No special patient preparation is required. Fasting is not necessary. Patients should inform their healthcare provider of any recent travel to endemic areas, tick exposure, blood transfusion history, or immunosuppression, as these factors influence result interpretation.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Babesiosis is a tick-borne disease caused by Babesia parasites that infect red blood cells. Babesia divergens is the primary species causing human babesiosis in Europe. The disease can range from asymptomatic to severe, particularly in individuals without a spleen, elderly patients, or those with weakened immune systems. Severe cases may lead to hemolytic anemia, jaundice, renal failure, and even death if left untreated. This antibody test is an important tool for diagnosis, especially in endemic areas during tick season. Treatment typically involves antiprotozoal medications such as atovaquone plus azithromycin or clindamycin plus quinine.

Frequently asked questions

How is babesiosis transmitted besides tick bites?
While tick bites are the primary transmission route, babesiosis can also be transmitted through contaminated blood transfusions or from mother to fetus during pregnancy. Blood donors are typically screened in endemic areas to prevent transfusion-transmitted infections.
When should I have this test done after a tick bite?
It typically takes 1-4 weeks after infection for antibodies to become detectable in the blood. If you develop symptoms within this period, your healthcare provider may recommend testing. However, if you were recently bitten and have no symptoms, your provider may recommend waiting and monitoring before testing.
Do I need to fast before this test?
No fasting is required for this test. You can eat and drink normally before having your blood drawn.
Can this test distinguish between current and past infection?
This test detects antibodies but cannot definitively distinguish between active and past infections. Your healthcare provider may order additional tests, such as PCR or blood smear microscopy, to confirm whether you have an active infection requiring treatment.
Is babesiosis the same as Lyme disease?
No, babesiosis and Lyme disease are different diseases caused by different pathogens. Lyme disease is caused by bacteria (Borrelia burgdorferi), while babesiosis is caused by a parasite (Babesia). Both are transmitted by the same tick species, so co-infection is possible. Testing for both conditions may be recommended in endemic areas.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 15, 2026. · Read our editorial policy