Bedaquilineisltgenotyp

Published: August 9, 2026Updated: August 16, 2026

This test checks whether the bacteria causing your tuberculosis (TB) is likely to respond to bedaquiline, an antibiotic used to treat drug-resistant TB.

Quick summary

{"Bedaquiline susceptibility testing helps doctors choose the right antibiotic for drug-resistant tuberculosis","The test uses a genotype method to detect genetic changes (mutations) associated with bedaquiline resistance","Results help guide personalized treatment plans for patients with drug-resistant TB","Sample is collected from blood (serum)","This test is specifically used when standard TB treatments are not effective"}

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC: 96107-8
Short code: BDQSUSP
Synonyms: Bedaquiline Islt Genotyp
Category: chemistry
Sample: serum
Container: Sterile, leak-proof screw-cap container or mycobacterial transport medium container; for serum: red-top or serum separator tube (SST)
Units: N/A
Fasting: false
Population: adult
Sex: all
Age range: ≥ 0 years
Method: genotyping
CPT: 87556
SNOMED: 446931000124100
Specimen volume: 5-10 mL for sputum or other respiratory specimens; 3-5 mL serum; minimum 1 mL accepted for molecular testing
Stability: Specimens should be transported to laboratory within 24 hours at 2-8°C. For delayed processing, store at -70°C or below. Serum samples stable at 2-8°C for 7 days; frozen at -20°C or below for extended storage.
Hemolysis max: 500
Lipemia max: 1000
Icterus max: 500
TAT: 24–72 hours
Order: routine

What is this test?

The Bedaquiline Susceptibility Test (Genotype) is a laboratory test that determines whether the tuberculosis (TB) bacteria in your body is likely to be killed by bedaquiline, a special antibiotic used to treat drug-resistant forms of tuberculosis. The 'genotype' method means the test looks for specific genetic mutations in the bacteria that are known to make the drug less effective.

Why is this test performed?

This test is performed when a patient has been diagnosed with tuberculosis that has not responded to standard first-line antibiotics. It helps healthcare providers determine if bedaquiline will be an effective treatment option. TB bacteria can develop resistance to antibiotics, making treatment more challenging. This test guides doctors in selecting the most appropriate medications for your specific condition.

How is the sample collected?

A blood sample will be drawn from a vein in your arm. The sample will be sent to a specialized laboratory where technicians will analyze it using genetic (DNA) testing methods to detect mutations associated with bedaquiline resistance.

What do the results mean?

The test result will indicate whether genetic mutations associated with bedaquiline resistance were detected. If no resistance mutations are found, the TB bacteria is likely susceptible to bedaquiline, meaning the drug should be effective. If resistance mutations are detected, your doctor will need to consider alternative treatment options. Your healthcare provider will explain the results and their implications for your treatment plan.

Reference range

Susceptible (no resistance-associated mutations detected) or Resistant (mutations in atpE, gyrA, gyrB, or rv0678 genes identified). Results reported as mutation detected or not detected.N/A

Specimen: serum

No fasting required. Specimen should be collected prior to initiation of bedaquiline therapy when possible. Inform laboratory of current antimicrobial therapy and relevant clinical history.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Frequently asked questions

Do I need to fast before this test?

No, fasting is not required for this blood test. You can eat and drink normally before the test.

How long does it take to get results?

The test requires specialized genetic analysis and may take several days to a week to complete. Your healthcare provider will inform you when results are available.

Is this test painful?

You may feel a brief sting or pinch when the blood is drawn, but the discomfort is minimal and temporary. The procedure is similar to routine blood tests.

Will this test determine if I need bedaquiline?

This test helps your doctor decide if bedaquiline is likely to work against your TB infection. However, your doctor will consider multiple factors, including other test results and your overall health, when making treatment decisions.

Are there any risks from this test?

The risks are minimal and include slight bruising, bleeding, or dizziness at the injection site. These are rare and usually resolve quickly.

Sources

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy