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Understanding Your Laboratory Blood Test: What It Is, How It Is Done, and What Your Results Mean

Published: August 9, 2026Updated: August 16, 2026

A saliva test that screens for the presence of benzodiazepine medications in your system.

Quick summary

{"Detects common benzodiazepine drugs like Valium, Xanax, and Ativan","Used to monitor medication compliance or check for drug use","Results are preliminary and may require confirmation testing","Non-invasive sample collection using oral fluid","Can detect recent use within hours to days"}

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
73662-9
Short code
BENZSAL
Synonyms
Benzodiazepines Pnl Sal Scn
Category
chemistry
Sample
serum
Container
Saliva/oral fluid collection device (e.g., Quantisal, Intercept, Oral-Eze, or specialized drug testing collection tube)
Units
N/A
Ref low
10
Ref high
50
Fasting
false
Population
adult
Sex
all
Age range
1–99 years
Method
screen
CPT
80307
SNOMED
362880008
Specimen volume
1-2 mL of oral fluid as collected per device instructions
Stability
Refrigerated (2-8°C): 7 days; Frozen (-20°C): 30 days; Room temperature: 24-48 hours per device specifications
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

This laboratory test measures specific substances in a sample of your blood so your doctor can better understand how your body is working. It may be ordered to screen for certain conditions, help confirm a diagnosis, monitor a health problem you already have, or check how well a treatment is working. Your doctor might include it in a routine checkup or order it because you have symptoms that need a closer look.

The Benzodiazepines Panel (Saliva) test is a screening test that detects the presence of benzodiazepine drugs in your saliva (oral fluid). Benzodiazepines are prescription medications commonly used to treat anxiety, insomnia, seizures, muscle spasms, and as sedatives before medical procedures. This test uses a screening method to identify if any common benzodiazepines are present in your system.

A sample of your blood is usually drawn from a vein in your arm by a trained member of our staff. An elastic band is placed around your upper arm, the skin is cleaned with an antiseptic, and a small needle collects the blood into a sealed tube. The process takes only a few minutes, and you may feel a brief sting or pinch. Afterward, pressure and a bandage are applied to the site, and you can usually return to your normal activities right away.

A healthcare provider will collect a saliva sample by placing a special collection device in your mouth to absorb oral fluid. The process is simple, non-invasive, and takes just a few minutes. You may be asked to avoid eating, drinking, smoking, or chewing gum for a short time before sample collection to ensure accurate results.

Your results are compared with a reference range, which reflects the values seen in most healthy people. Results within that range generally suggest normal function, while values that are higher or lower may point to a condition that needs follow-up or further testing. A single abnormal value does not always mean you are sick, since medications, diet, hydration, and other factors can affect the numbers. Your doctor will interpret your results together with your symptoms, medical history, and physical exam, and will contact you if any changes to your care are needed.

A negative result means no benzodiazepines were detected in your saliva at the time of testing. A positive result indicates that benzodiazepines were detected, but this is a preliminary finding. Positive results typically require confirmation with a more specific test (like gas chromatography-mass spectrometry) to identify the exact substance and confirm the result.

Reference range

Negative (Cutoff: typically 10-50 ng/mL depending on specific benzodiazepine and assay; positive results require confirmation by GC-MS or LC-MS/MS)N/A

Specimen: serum

Avoid eating, drinking, or using oral hygiene products for at least 10-30 minutes prior to specimen collection. Do not rinse mouth with water or mouthwash immediately before collection.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

This test is commonly used for medication compliance monitoring, ensuring patients are taking their prescribed benzodiazepines as directed. It may also be used in substance abuse treatment programs, workplace drug testing, or forensic investigations. Healthcare providers use the results to guide treatment decisions, assess for potential drug interactions, or evaluate if a patient is using benzodiazepines that were not prescribed.

Benzodiazepines include commonly prescribed medications such as diazepam (Valium), alprazolam (Xanax), lorazepam (Ativan), clonazepam (Klonopin), and temazepam (Restoril). These medications can be detected in saliva typically within hours of use and up to 2-3 days after last dose, depending on the specific drug and individual factors.

Frequently asked questions

Will this test show exactly how much medication I took?
No. This is a screening test that detects the presence or absence of benzodiazepines but does not measure the exact amount. Quantitative (amount) testing requires a confirmatory blood test performed in a reference laboratory.
Can I test positive if I only took my medication as prescribed?
Yes. If you have taken a prescribed benzodiazepine, it will likely be detected by this test. Always inform the testing facility about all medications you are taking, including prescriptions, over-the-counter drugs, and supplements.
How long do benzodiazepines stay detectable in saliva?
Detection time varies depending on the specific benzodiazepine, dosage, frequency of use, and individual metabolism. Generally, most benzodiazepines can be detected in saliva for 24-72 hours after last use, though some longer-acting versions may be detectable longer.
Do I need to prepare for this test?
Follow any specific instructions provided by your healthcare provider. You may be asked to avoid eating, drinking, smoking, or using oral products (like mouthwash) for a short period before sample collection. Inform the collector about any medications or supplements you have recently taken.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy