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Benzodiazserplqlscn

Published: August 9, 2026Updated: August 16, 2026

A screening test to detect the presence of benzodiazepine drugs in your blood.

Quick summary

{"This test checks if benzodiazepine medications are present in your blood","It helps doctors monitor drug levels or investigate suspected overdose","Common benzodiazepines include diazepam, lorazepam, and alprazolam","The test uses a blood sample drawn from a vein","Results are typically reported as positive or negative"}

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
46976-7
Short code
BENZO-S
Synonyms
Benzodiaz SerPl Ql Scn
Category
chemistry
Sample
serum
Container
Red-top (no additive) or serum separator tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
screen
CPT
80307
SNOMED
396877001
Specimen volume
1-2 mL of serum or plasma
Stability
Room temperature: 24 hours; Refrigerated (2-8°C): 7 days; Frozen (-20°C or below): 30 days
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

The benzodiazepine test is a screening test that detects whether benzodiazepine medications are present in your blood. Benzodiazepines are a class of prescription drugs commonly used to treat anxiety, insomnia, seizures, and muscle spasms. Examples include diazepam (Valium), lorazepam (Ativan), alprazolam (Xanax), and clonazepam (Klonopin).

This test uses a blood sample to screen for the presence of these drugs. It is not typically used to measure exact drug levels, but rather to determine whether any benzodiazepine is present in your system.

Why might I need this test?

Your doctor may order this test for several reasons: to monitor if you are taking your prescribed medication, to investigate symptoms of suspected overdose or poisoning, to check for drug use before surgery, or to evaluate unexplained symptoms such as excessive drowsiness, confusion, or breathing problems.

How is the test performed?

A healthcare professional will draw a small amount of blood from a vein in your arm using a needle. The blood sample is then sent to a laboratory for analysis. The test itself involves adding the blood sample to a test system that detects the presence of benzodiazepine compounds.

What do the results mean?

Results are typically reported as either positive or negative. A positive result means benzodiazepines were detected in your blood. A negative result means no benzodiazepines were detected. It is important to discuss your results with your doctor, who will interpret them based on your medical history and the reason for testing.

Reference range

Negative (Cutoff: 200 ng/mL for nordiazepam or equivalent benzodiazepine metabolite)N/A

Specimen: serum

No fasting required. Inform the laboratory of all prescription medications, over-the-counter drugs, and supplements being taken, as benzodiazepines are commonly prescribed and results may be expected.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings2

Frequently asked questions

Do I need to fast before this test?
No, fasting is not required for this test. You can eat and drink normally before having your blood drawn. However, always follow any specific instructions given by your doctor.
How long do benzodiazepines stay in blood?
The duration varies depending on the specific medication and individual factors. Short-acting benzodiazepines may be detectable for 1-3 days, while longer-acting ones can be detected for up to a week or more. Factors such as metabolism, age, liver function, and dosage affect how long the drug remains in your system.
Will my prescription affect the test results?
Yes, if you have a valid prescription for benzodiazepines, a positive result is expected. Always inform your doctor about all medications you are taking, including prescriptions, over-the-counter drugs, and supplements.
Is this test accurate?
This is a screening test, which means it is designed to detect the presence of benzodiazepines. While generally reliable, screening tests can occasionally produce false positives or false negatives. If needed, your doctor may order a more specific confirmatory test to verify the results.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy