Beta1globcsfelphmcnc
This test measures the level of beta 1 globulin protein in the fluid surrounding your brain and spinal cord to help diagnose neurological conditions.
{"The test uses a sample of cerebrospinal fluid (CSF) collected through a lumbar puncture","Beta 1 globulin is a protein that helps transport substances and support immune function","Abnormal levels may indicate infections, inflammation, or diseases affecting the nervous system","Results help doctors distinguish between different neurological conditions","The test is part of a broader protein analysis called electrophoresis"}
Key facts at a glance
- LOINC
- 55914-6
- Short code
- CSF B1 GLOB
- Synonyms
- Beta1 Glob CSF Elph-mCnc
- Category
- chemistry
- Sample
- csf
- Container
- Sterile CSF collection tube, polypropylene, free of preservatives. Collect in sequentially numbered tubes (Tube 1-4) for CSF analysis; typically Tube 3 or 4 is used for protein electrophoresis.
- Units
- N/A
- Ref low
- 2
- Ref high
- 7
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- ≥ 0 years
- Method
- electrophoresis
- CPT
- 82985 (CSF electrophoresis, includes beta-1 globulin fraction)
- SNOMED
- 104361006 |Cerebrospinal fluid electrophoresis (procedure)|; 57178001 |Beta-1 globulin measurement (procedure)|
- Specimen volume
- Minimum 0.5 mL CSF; preferably 1-2 mL for adequate protein electrophoresis analysis.
- Stability
- CSF is stable for protein electrophoresis analysis at room temperature for up to 4 hours, refrigerated (2-8°C) for up to 72 hours. For prolonged storage, freeze at -20°C or below; avoid repeated freeze-thaw cycles.
- Hemolysis max
- 200
- TAT
- 24–72 hours
- Order
- routine
What is this test?
The Beta 1 Globulin test measures the amount of a specific protein called beta 1 globulin in your cerebrospinal fluid (CSF). CSF is a clear, protective fluid that surrounds your brain and spinal cord. The test is performed using a technique called electrophoresis, which separates different proteins in the fluid so they can be measured individually.
How is the sample collected?
CSF is collected through a procedure called a lumbar puncture, commonly known as a spinal tap. During this procedure, a healthcare provider inserts a thin needle into the lower back to withdraw a small amount of CSF from the space around the spinal cord. The area is first numbed with a local anesthetic to minimize discomfort. After the sample is collected, you may be asked to lie flat for a short period to reduce the risk of headache.
Why is beta 1 globulin important?
Beta globulins are a group of proteins in the blood and CSF that serve important functions. They help transport hormones, vitamins, and lipids throughout the body, and play a role in immune system function. In the cerebrospinal fluid, these proteins can indicate the health of the central nervous system. Changes in beta 1 globulin levels may suggest underlying conditions that affect the brain or spinal cord.
What should I expect during the test?
Before the test, your doctor will explain the procedure and any necessary preparations. You may be asked to lie on your side or sit leaning forward during the lumbar puncture. The procedure itself takes about 15-30 minutes. You may feel some pressure or mild discomfort when the needle is inserted. After the sample is taken, drink plenty of fluids and rest as recommended to reduce the chance of a post-procedure headache.
Reference range
Beta-1 globulin fraction typically comprises 2-7% of total CSF protein. Absolute concentration reference ranges vary by laboratory; commonly reported as percentage of total protein fraction.N/A
No special patient preparation required. Fasting is not necessary. Lumbar puncture should be performed under standard sterile technique by qualified healthcare provider.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings2
Frequently asked questions
Is the lumbar puncture painful?
How long does it take to get results?
Are there any risks associated with this test?
Do I need to fast before this test?
Sources
- 1
- 2
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy