Beta2globmfrurelph
This test measures beta-2 globulin protein in urine using electrophoresis to help detect kidney function problems.
{"Beta-2 globulin is a small protein normally filtered by kidney tubules","Elevated levels in urine may indicate kidney tubule damage","The test uses electrophoresis to separate and measure protein fractions","Results help doctors diagnose and monitor kidney conditions","A urine sample is all that is needed for this test"}
Key facts at a glance
- LOINC
- 32737-9
- Short code
- UB2GLOB
- Synonyms
- Beta2 Glob MFr Ur Elph
- Category
- chemistry
- Sample
- urine
- Container
- Sterile, leak-proof urine collection container; 24-hour collection requires a 3-liter container without preservatives (or with appropriate preservative if specified by laboratory). For random urine, a clean-catch midstream specimen container is used.
- Units
- N/A
- Ref low
- 0
- Ref high
- 150
- Critical range
- 7.2 N/A – 7.6 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- electrophoresis
- CPT
- 84165
- SNOMED
- 313838007
- Specimen volume
- Random urine: 10-50 mL minimum; 24-hour collection: complete 24-hour volume (typically 1000-2000 mL total). For electrophoresis, a minimum concentrated volume of 10-20 mL is preferred after concentration steps.
- Stability
- Urine stable at room temperature (15-25°C) for up to 2 hours; refrigerated (2-8°C) for up to 7 days; frozen at -20°C or below for up to 1 month. For electrophoresis analysis, refrigeration is preferred and samples should be analyzed within 72 hours when possible.
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 24–72 hours
- Order
- routine
What is this test?
The Beta-2 Globulin/Protein Total in Urine by Electrophoresis test measures the amount of beta-2 globulin protein in your urine. Beta-2 microglobulin is a small protein that is normally produced by most cells in your body and is freely filtered by the kidneys. Under normal conditions, only very small amounts should appear in urine because the kidneys reabsorb it. This test uses a technique called electrophoresis, which separates different proteins in the urine so each type can be measured individually.
Why do I need this test?
Your doctor may order this test if they suspect you have kidney problems, particularly involving the renal tubules (the tiny tubes in the kidneys that filter blood). It helps detect early damage to kidney tubules before other symptoms become apparent. The test is also useful for monitoring patients who have received kidney transplants, as elevated levels may indicate transplant rejection. Additionally, it can help identify certain types of poisoning, such as exposure to cadmium or mercury, which can damage kidney tubules.
How is the test done?
A urine sample is collected, usually as a clean-catch midstream sample. You will be given a sterile container and instructions on how to collect the urine properly. For the clean-catch method, you first clean the genital area, begin urinating, and then collect the middle portion of the urine stream in the container. The sample is then sent to a laboratory where electrophoresis is used to separate and measure the beta-2 globulin protein along with other protein fractions in the urine.
What do the results mean?
Normal results typically show very low or undetectable levels of beta-2 globulin in urine. Elevated levels indicate that the kidneys are not properly reabsorbing this protein, which suggests damage to the renal tubules. Higher levels generally indicate more severe kidney damage. Your doctor will interpret your results in combination with other tests and your overall health condition to make an accurate diagnosis.
Reference range
Beta-2 globulin fraction is typically not detectable or present in trace amounts (less than 5% of total urinary protein) in healthy individuals. Total urine protein reference range: <150 mg/24 hours or <10 mg/dL in random urine. The beta-2 globulin band, when expressed as a percentage of total protein, is generally less than 5%.N/A
No special preparation required. Patients should maintain normal hydration. For 24-hour collection, discard first morning void and collect all subsequent urine for 24 hours including the next morning void. Avoid vigorous exercise prior to collection as it may transiently elevate protein levels.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Frequently asked questions
Is there any preparation needed before the test?
Are there any risks with this test?
How long does it take to get results?
What happens if my results are abnormal?
Can I do anything to improve my results?
Sources
- 1
- 2
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy