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Bglobulinmfrcsfelph

Published: August 9, 2026Updated: August 16, 2026

This test measures beta globulin protein levels in cerebrospinal fluid (CSF) using electrophoresis to help diagnose neurological conditions.

Quick summary

{"The test analyzes cerebrospinal fluid collected via lumbar puncture","Beta globulin is a protein fraction that helps detect infections and inflammatory conditions of the brain and nervous system","Abnormal results may indicate multiple sclerosis, infections, or other neurological disorders","The procedure is generally safe but carries rare risks like headache or infection","Results are interpreted alongside other clinical findings by your healthcare provider"}

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
13976-6
Short code
BETA-GLOB-CSF
Synonyms
B-Globulin MFr CSF Elph
Category
chemistry
Sample
csf
Container
Sterile, leak-proof polypropylene collection tube for CSF
Units
N/A
Ref low
2.2
Ref high
5.7
Critical range
7.2 N/A – 7.6 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
electrophoresis
CPT
82985
SNOMED
104025008
Specimen volume
1-2 mL of cerebrospinal fluid
Stability
Ambient: 4 hours; Refrigerated (2-8°C): 24 hours; Frozen (-20°C or below): up to 1 month for electrophoretic analysis
Hemolysis max
200
TAT
24–72 hours
Order
routine

What is this test?

The CSF Beta Globulin Electrophoresis test measures the amount of beta globulin protein as a percentage of total protein in your cerebrospinal fluid (CSF). CSF is the clear fluid that surrounds and protects your brain and spinal cord. Electrophoresis is a laboratory technique that separates different protein types in the fluid so they can be measured individually.

Why is this test performed?

Your doctor may order this test to help diagnose or monitor conditions affecting your central nervous system. The test can detect abnormal patterns of protein in the CSF, which may indicate inflammation, infection, bleeding, or autoimmune conditions. It is particularly useful in evaluating diseases like multiple sclerosis, meningitis, encephalitis, and certain cancers affecting the nervous system.

How is the test performed?

A healthcare provider will collect CSF using a procedure called a lumbar puncture (spinal tap). You will lie on your side or sit leaning forward. The provider cleans your lower back and inserts a thin needle between two vertebrae to withdraw a small amount of fluid. The sample is then sent to a laboratory where electrophoresis is used to separate and measure the beta globulin protein fraction.

What should I expect during the procedure?

During the lumbar puncture, you may feel some pressure or a brief stinging sensation. The procedure typically takes 15-30 minutes. Afterward, you should lie flat for 1-2 hours to reduce the risk of a spinal headache. Drink plenty of fluids and avoid strenuous activities for 24 hours.

Reference range

2.2-5.7% of total CSF protein (laboratory-specific reference values apply)N/A

Specimen: csf

No special patient preparation required. Fasting is not necessary prior to lumbar puncture. Inform the patient about the procedure and obtain informed consent.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings2

Frequently asked questions

How do I prepare for a lumbar puncture?
Inform your doctor about all medications you take, especially blood thinners. You may need to stop certain medications before the procedure. Your doctor will give you specific instructions. It is helpful to empty your bladder before the procedure and wear comfortable, loose-fitting clothing.
Are there any risks with this test?
The most common side effect is a headache that may last for several days, occurring in about 10-30% of patients. Other rare risks include back pain, bleeding, infection, or nerve injury. Lying flat after the procedure and drinking fluids can help prevent headaches.
How long does it take to get results?
Results are typically available within 1-3 days, depending on the laboratory. Your doctor will discuss the results with you at a follow-up appointment.
Do I need to fast before this test?
No, fasting is not required for this test. You can eat and drink normally before the procedure.
What happens if my results are abnormal?
An abnormal result does not necessarily mean you have a serious condition. Your doctor will consider your symptoms, medical history, and other test results to determine the cause. Additional tests may be needed to confirm a diagnosis.
  1. 1
    Mayo Clinic - Lumbar puncture (spinal tap)Source
  2. 2
    MedlinePlus - CSF protein electrophoresisSource
  3. 3
    Johns Hopkins Medicine - Cerebrospinal Fluid (CSF) AnalysisSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy