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Total Protein in Serum or Plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood, which includes albumin and other proteins like globulins.

Quick summary

["Your blood protein levels help assess hydration, liver function, and kidney health."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
72693-5
Short code
Big IGF-II SerPl-mCnc
Synonyms
Big IGF-II SerPl-mCnc
Category
hormone
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Doctors may order a total protein test to check for conditions like malnutrition, liver disease, kidney problems, or certain types of infections. It can also help diagnose conditions like multiple myeloma or inflammatory diseases.

What Does It Mean If Results Are Abnormal?

Low protein levels might suggest malnutrition, liver disease, or kidney issues. High levels could indicate dehydration, multiple myeloma, or certain autoimmune conditions. Your doctor will interpret results in the context of your overall health.

How Is This Test Performed?

A blood sample is taken from a vein, usually in your arm. The blood is then sent to a lab where it is analyzed to determine the total protein concentration.

What Are Common Causes of Abnormal Results?

Changes in protein levels can be caused by diet, medical conditions (such as kidney or liver disease), medications, or certain health conditions like infections or inflammatory diseases.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Protein

Frequently asked questions

What does a total protein test measure?
This test measures the combined amount of all proteins in your blood, including albumin and globulins.
How often should I get this test?
Your doctor will determine how often you need this test based on your medical history, symptoms, and overall health. It may be part of routine check-ups or follow-up tests for certain conditions.
Can diet affect my protein test results?
Yes, diet can influence protein levels. Eating a balanced diet with adequate protein intake can help maintain normal levels, but extreme dietary changes or deficiencies may affect results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy