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Bilirubin Analysis (Serum or Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of bilirubin in your blood. Bilirubin is a yellow pigment produced when your body breaks down old red blood cells. It helps your liver process waste and remove it from your body.

Quick summary

["Bilirubin levels can indicate liver function or potential bile duct blockages."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
95229-1
Short code
BTCYTO
Synonyms
Biliary Neo Chrom Analysis Tiss
Category
chemistry
Sample
serum
Container
Sterile tissue collection container with sterile saline or RPMI 1640 transport medium
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–99 years
Method
Chromosome analysis (Karyotyping), Fluorescence in situ hybridization (FISH), Chromosomal microarray analysis (CMA)
CPT
88264
SNOMED
38441000114603
Specimen volume
Fresh tissue specimen (minimum 1 cm³) collected under sterile conditions; biopsy core or resected tissue fragment
Stability
Refrigerate at 2-8°C; deliver to laboratory within 24 hours of collection. For longer transport, use RPMI transport medium at 4°C. Do not freeze.
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
168–720 hours
Order
routine

Why This Test Matters

Your doctor may order this test to check for liver problems, such as hepatitis, cirrhosis, or blockages in your bile ducts. It can also help diagnose conditions like gallstones or certain types of cancer. High levels might suggest jaundice, while low levels could indicate hemolytic anemia or liver disease.

What to Expect Before the Test

You may be asked to fast for 8–12 hours before the test if it involves a blood draw. No special preparation is needed for a urine test. If you have any concerns or conditions (like diabetes), let your doctor know before the test.

How the Test Works

A small blood sample is taken from your arm, or urine may be collected in a container. The sample is then analyzed to measure bilirubin levels using a specialized lab test. Results are compared to standard ranges to identify any abnormalities.

Possible Results and Next Steps

If your bilirubin levels are outside the normal range, your doctor may recommend further testing, such as additional blood tests, imaging (like an ultrasound), or a liver biopsy. Follow-up may include monitoring symptoms or adjusting medications if needed.

Reference range

No clinically significant chromosomal abnormalities detected. Normal female karyotype (46,XX) or normal male karyotype (46,XY). Results interpreted in conjunction with histopathological findings.N/A

Specimen: serum

No fasting required. Patient should inform clinician of any recent blood transfusions, as this may affect chromosomal analysis results. Tissue sample collection is performed via surgical biopsy or resection by qualified medical personnel.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Bilirubin Test

Frequently asked questions

What causes elevated bilirubin?
Elevated bilirubin can be due to liver disease, bile duct blockages, hemolysis (destruction of red blood cells), or certain medications. If you notice yellowing of your skin or eyes, contact your doctor.
What if my bilirubin is low?
Low bilirubin levels are less common and may occur with certain blood disorders or liver conditions. Your doctor will review your full medical history and other test results to determine the cause.
Can I eat before this test?
For blood-based tests, fasting may be required. For urine tests, no fasting is needed unless specified by your doctor. Always follow their instructions to ensure accurate results.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy