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Bilirubin, Whole Blood — Substance Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures bilirubin in whole blood. It may help evaluate bile production, liver function, or the breakdown of red blood cells.

Quick summary

["Abnormally high bilirubin may reflect liver dysfunction or increased red blood cell breakdown."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
97770-2
Short code
Bilirub BldC-sCnc
Synonyms
Bilirub BldC-sCnc
Category
liver
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What is this test?

Bilirubin is a yellow pigment made during the breakdown of heme, the oxygen-carrying part of red blood cells. It is processed by the liver and then removed in bile. This test measures the concentration of bilirubin in a whole-blood sample.

Why might I need this test?

A clinician may order this test as part of an evaluation of jaundice, liver disease, gallbladder or bile duct problems, or suspected hemolysis. It may also be used to monitor certain medications or treatments that can affect the liver.

How is the test performed?

A blood sample is collected, usually by a vein or a finger stick, and the amount of bilirubin in the whole blood is measured. The laboratory may use an instrument-based assay; the method is not specified by the test slug.

How do I prepare for the test?

Fasting is usually not required unless your clinician specifically requests it. Tell the healthcare provider about any medicines or supplements you are taking, and follow any preparation instructions included with your test order.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Whole Blood Bilirubin

Frequently asked questions

What does a high bilirubin result mean?
It may indicate that the liver is not processing bilirubin normally, that bile flow is obstructed, or that red blood cells are breaking down faster than usual. Your clinician will interpret the result with your symptoms and other tests.
Does a low bilirubin result usually cause concern?
Low bilirubin levels are generally less clinically significant than elevated levels. However, your clinician should interpret the result in the context of your overall health and other test findings.
Does this test require fasting?
Fasting is commonly unnecessary, but requirements can vary. Prolonged fasting may temporarily affect bilirubin, so follow the preparation instructions provided by your healthcare professional.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy