Skip to content

Bilirubin — Mass Concentration

Published: August 9, 2026Updated: August 16, 2026

A quantitative test that measures the amount of bilirubin in a sample, most commonly serum or plasma.

Quick summary

["This test measures bilirubin levels, which can help evaluate liver function and the breakdown of red blood cells."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
14422-0
Short code
Bilirub Prt-mCnc
Synonyms
Bilirub Prt-mCnc
Category
liver
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

Bilirubin is a yellow pigment produced when the body breaks down old red blood cells. This test measures the amount of bilirubin in the sample.

Why might I need this test?

Doctors may order this test as part of a liver panel, to check for jaundice, or to help evaluate anemia caused by increased red blood cell breakdown.

How is the test performed?

A blood sample is usually collected and tested in a laboratory. The sample required may be serum or plasma, depending on the test ordered and the laboratory's instructions.

How do I prepare for the test?

Routine bilirubin testing usually does not require fasting, but your healthcare provider may give specific preparation instructions. Tell the laboratory if you are pregnant or have recently had a blood transfusion.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

A higher bilirubin level may occur with liver inflammation or disease, blocked bile flow, or increased destruction of red blood cells. Mild elevations can also occur with harmless conditions such as Gilbert syndrome, particularly during illness, stress, fasting, or exercise. Low bilirubin levels are uncommon and are generally not considered a problem on their own.

Short name

Bilirubin

Frequently asked questions

What does a bilirubin test measure?
It measures the concentration of bilirubin, a pigment made as the body breaks down old red blood cells.
Does a high bilirubin level always mean I have liver disease?
No. High bilirubin can have several causes, including liver conditions, bile duct blockage, and increased red blood cell breakdown. The result is interpreted with other tests and your symptoms.
Do I need to fast before this test?
Fasting is usually not required for routine bilirubin testing. Follow any specific instructions from your healthcare provider or laboratory.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy