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Bilirubin, Serum/Plasma or Blood — Substance Concentration

Published: August 9, 2026Updated: August 16, 2026

Measures the amount of bilirubin in a blood sample to help evaluate liver function and the breakdown of red blood cells.

Quick summary

["Abnormally high bilirubin may signal a liver problem or increased red blood cell breakdown."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
77137-8
Short code
Bilirub SerPlBld-sCnc
Synonyms
Bilirub SerPlBld-sCnc
Category
liver
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

A bilirubin test measures bilirubin, a yellow pigment made when the body breaks down old red blood cells. Bilirubin is processed by the liver and can be measured in serum, plasma, or certain whole-blood specimens.

Why might I need this test?

This test may be ordered to evaluate jaundice, investigate suspected liver disease, or assess problems related to increased red blood cell breakdown. It may also be included as part of a broader liver function or anemia evaluation.

How is the test performed?

A laboratory professional draws a blood sample, usually from a vein. The sample is analyzed to determine the concentration of bilirubin in the blood.

How do I prepare for the test?

Fasting is usually not required, but follow any instructions from your healthcare professional or laboratory. Tell the care team if you are pregnant or taking medicines that may affect the liver or bilirubin levels.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Bilirubin test

Frequently asked questions

What does a high bilirubin level mean?
It may be associated with liver disease, blockage of bile drainage, or increased red blood cell breakdown. Other tests and clinical findings are needed to determine the cause.
Does a bilirubin test require fasting?
Fasting is generally not required for this test unless your healthcare professional specifically requests it. Follow the preparation instructions provided by your laboratory.
Can jaundice be present with a bilirubin result?
Yes. Yellowing of the skin or whites of the eyes can occur when bilirubin levels rise, but symptoms alone cannot identify the underlying cause.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy