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Total Protein Mass Concentration in 24-Hour Urine Collection

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein excreted in your urine over a 24-hour period. Protein in urine can sometimes indicate kidney issues or other health conditions.

Quick summary

["This test helps assess kidney function and detect protein loss in urine over time."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
17793-1
Short code
ULC24
Synonyms
BJ Protein 24h Ur-mCnc
Category
chemistry
Sample
urine
Container
24-hour urine collection container (sterile, preservative-free or with thymol/boric acid preservative)
Units
N/A
Ref low
1
Ref high
5
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
Nephelometry or Turbidimetry (immunoprecipitation)
CPT
83883
SNOMED
104159003
Specimen volume
Complete 24-hour urine collection (minimum 10 mL aliquot from total volume)
Stability
Refrigerated (2-8°C): 7 days; Frozen (-20°C): 30 days; Room temperature: 2 hours
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
24–72 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test if you have symptoms like swelling, frequent urination, or if they suspect kidney problems. It can also be used to monitor chronic conditions like kidney disease or certain types of kidney damage.

What Does the Test Involve?

You’ll collect all your urine for a full 24-hour period in a special container. This ensures an accurate measurement of protein loss. The collected urine is then sent to a lab for testing.

What Are Common Causes of High or Low Protein Levels?

High protein levels in urine (proteinuria) can be caused by kidney diseases, diabetes, or other conditions that damage kidney filters. Low levels are less common and may not indicate a problem unless part of a broader evaluation.

What Should You Expect After the Test?

After collecting urine, you’ll return it to your healthcare provider or lab. Results take time to process, and your provider will discuss them with you during a follow-up visit.

Reference range

Free kappa light chains: <7.5 mg/24h; Free lambda light chains: <3.5 mg/24h; Kappa/Lambda ratio: 1.0-5.0 (varies by laboratory)N/A

Specimen: urine

No special preparation required. Patient should maintain normal hydration and usual diet. Avoid strenuous exercise prior to collection.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

24-Hour Urine Protein Test

Frequently asked questions

How is this test different from a random urine protein test?
A 24-hour urine protein test measures total protein loss over a full day, giving a more accurate picture of long-term protein excretion. A random urine protein test only checks protein at one point in time and may not reflect daily levels.
What if I have kidney disease and my results are normal?
Normal results don’t always mean your kidney disease is under control. Your provider may recommend follow-up tests or monitoring to track protein levels over time, especially if you have symptoms or risk factors.
Can diet affect this test?
Yes, certain foods or medications may temporarily affect protein excretion. Your provider may advise dietary restrictions or timing of the test to ensure accurate results, such as avoiding high-protein foods before collection.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy