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: 24-Hour Urine Protein Excretion Rate

Published: August 9, 2026Updated: August 16, 2026

: This test measures the total amount of protein your kidneys release into urine over a full 24-hour period, expressed as a rate. It helps assess kidney function and detect abnormal protein loss.

Quick summary

[": A 24-hour urine protein rate shows how much protein your kidneys are leaking over a day, a key signal of kidney health."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
46084-0
Short code
UFLCT
Synonyms
BJ Protein 24h Ur-mRate
Category
chemistry
Sample
urine
Container
24-hour urine collection container (sterile, preservative-free or with appropriate stabilizer)
Units
N/A
Ref low
1.4
Ref high
7.6
Fasting
false
Population
adult
Sex
all
Age range
≥ 18 years
Method
Nephelometry
CPT
83883
SNOMED
104978001
Specimen volume
Complete 24-hour urine collection; minimum 10 mL aliquot required for testing
Stability
Stable for 7 days at 2-8°C; for longer storage, freeze at -20°C
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
24–72 hours
Order
routine

: What This Test Measures

: Over 24 hours, your kidneys filter waste from your blood while normally keeping most protein in the bloodstream. This test collects all the urine you produce in one day and measures the total protein in it, then reports the amount as a rate per unit of time. The result reflects how well your kidneys are holding onto protein.

: Why Your Doctor Ordered It

: Your clinician may order this test to check for kidney damage, monitor a known kidney condition, or evaluate symptoms such as foamy urine or swelling. It is often used when a simpler urine test suggests protein may be present, to confirm and quantify the amount.

: How the Collection Works

: You will be given a container to collect all urine for a full 24-hour period, typically starting after you discard your first morning urine. It is important to collect every sample, store the container as instructed (often cool), and return it to the lab promptly. Missing collections can make the result unreliable.

: What the Results Mean

: A higher protein rate generally indicates that more protein is passing through the kidneys than expected, which can point to kidney irritation or damage. Results are interpreted alongside your medical history, other urine and blood tests, and blood pressure. Your doctor will explain what your specific value means for you.

Reference range

Kappa free light chains: <6.7 mg/24h; Lambda free light chains: <2.3 mg/24h; Kappa/Lambda ratio: 1.4-7.6N/A

Specimen: urine

No special preparation required. Patient should maintain usual hydration and dietary habits during the 24-hour collection period

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

: The 24-hour urine protein rate is a classic marker of kidney health. Persistently elevated protein loss can be an early sign of kidney disease and is associated with conditions such as diabetes, high blood pressure, and glomerular disorders. Tracking this rate over time helps providers gauge disease activity and response to treatment. Because normal ranges vary by laboratory and by factors like age and pregnancy, results should always be interpreted by your clinician.

Short name

: 24h Urine Protein Rate

Frequently asked questions

: Do I need to fast before this test?
: Usually no fasting is required, but follow the specific instructions given by your lab or doctor, since some related tests may have preparation requirements.
: What happens if I miss one urine collection?
: Tell your doctor or lab. An incomplete collection can make the protein rate look falsely low, so they may ask you to repeat the 24-hour collection.
: Can I do this test if I am menstruating?
: Blood in the urine can affect results, so let your doctor know. They may recommend rescheduling the collection to a time when you are not menstruating.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy