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Protein in Urine (Quantitative)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of protein found in your urine, which can help detect kidney issues or other conditions affecting protein loss.

Quick summary

["Check for kidney problems or protein loss in urine."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
14795-9
Short code
UFLCH-INT
Synonyms
BJ Protein Ur-Imp
Category
chemistry
Sample
urine
Container
Sterile, leak-proof urine collection container; 24-hour urine container with preservative (toluene or thymol) if timed collection is requested
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
Immunofixation Electrophoresis (IFE); may include Immunonephelometry and Kappa/Lambda Free Light Chain Assay
CPT
86335
SNOMED
313414003
Specimen volume
10 mL random urine minimum; 24-hour collection: complete timed collection as instructed
Stability
Ambient: 2 hours; Refrigerated (2-8°C): 7 days; Frozen (-20°C or below): 30 days. For free light chain quantification, refrigerate immediately and analyze within 7 days.
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
24–72 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test if you have symptoms like swelling, frequent urination, or unexplained fatigue. It can also be used to monitor kidney function or diagnose conditions like kidney disease, diabetes, or certain infections.

What to Expect Before the Test

No special preparation is needed. You may be asked to collect a urine sample in a clean container at home or during a visit to a lab. If you’re using certain medications or have conditions like kidney disease, discuss this with your provider before testing.

How the Test Works

The test measures the total protein content in your urine. Protein in urine is usually not present in healthy individuals, so elevated levels may indicate problems like kidney damage or excessive protein loss.

Possible Results and Next Steps

Results are typically reported as a range (e.g., normal vs. elevated). High protein levels in urine may signal kidney issues, while very low levels may raise concerns about hydration or other health factors. Follow up with your provider to discuss results and next steps, such as further testing or treatment adjustments.

Reference range

Interpretation: No monoclonal free light chains (Bence Jones proteins) detected. Normal pattern shows polyclonal kappa and lambda free light chains, with kappa/lambda ratio within reference range. If monoclonal free light chains are present, typing (kappa or lambda) will be reported along with semiquantitative assessment.N/A

Specimen: urine

No special preparation required. A first morning void or 24-hour urine collection may be preferred as directed by the ordering physician. Patient should maintain normal hydration unless instructed otherwise.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Protein in urine can signal underlying health issues. Elevated levels may indicate kidney problems, diabetes, or other conditions causing protein loss. Low protein levels in urine may reflect dehydration or other factors, so results should always be interpreted by a healthcare provider in the context of your overall health.

Short name

Urine Protein Test

Frequently asked questions

What does a high protein level in urine mean?
A high protein level in urine may suggest kidney damage, inflammation, or conditions like diabetes. Your provider will review your results and symptoms to determine the best next steps, which could include additional tests or treatments.
How often should I get this test?
Your provider will decide how often you need this test based on your health history, symptoms, and other test results. Regular monitoring may be recommended if you have kidney disease, diabetes, or other conditions linked to protein loss in urine.
Can diet or medications affect this test?
Yes, certain foods (like high-protein diets) or medications (such as some diuretics or NSAIDs) may influence protein levels in urine. Always inform your provider about any medications or dietary changes before testing.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy