Prostate-Specific Antigen (PSA) and Urine Test for Prostate Health Analysis (with Genomic/Prostate-Specific Marker Screening)
This test measures prostate-specific markers in blood and urine to assess prostate health, including PSA levels and potential genetic or molecular indicators related to prostate function or disease.
["Helps evaluate prostate health, detect early signs of prostate issues, or monitor treatment response."]
Key facts at a glance
- LOINC
- 105589-6
- Short code
- BLPRMOL
- Synonyms
- Bladder & Prostate CA mltgn anlyss Tiss
- Category
- chemistry
- Sample
- serum
- Container
- Sterile tissue container or formalin-fixed paraffin-embedded (FFPE) tissue block; whole blood in EDTA tube may be required for germline testing
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- ≥ 18 years
- Method
- molgen
- CPT
- 81432
- SNOMED
- 426396005
- Specimen volume
- Tissue: minimum 5x5 mm section with >70% tumor cellularity; 10-20 mg fresh/frozen tissue; 1 mL whole blood for germline testing
- Stability
- FFPE tissue: stable at room temperature for 1 year; Fresh tissue: 24 hours at 4°C; Whole blood for germline testing: 7 days at 2-8°C; DNA extracted: stable for 1 year at -20°C
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 120–336 hours
- Order
- routine
What This Test Measures
The test includes measurements of prostate-specific antigen (PSA) in blood and urine, along with additional prostate-related biomarkers. PSA is a protein produced by prostate cells that can be elevated in conditions like benign prostatic hyperplasia (BPH), prostate cancer, or inflammation. Additional components may include genetic or molecular markers related to prostate tissue function or disease risk.
Why It’s Ordered
Your healthcare provider may recommend this test if you have symptoms like urinary changes, pain, or if you’re at higher risk for prostate issues. It may also be used during screening, monitoring for prostate cancer, or evaluating prostate health before or after treatment.
Sample Collection and Preparation
Blood and urine samples are collected separately. Blood is drawn from a vein, while urine is collected in a sterile container. These samples are sent to a lab for analysis using advanced techniques like immunoassay or molecular testing to detect PSA and other prostate-specific markers.
What to Expect Before the Test
No special preparation is typically needed for this test. For urine samples, ensure you’re well-hydrated but avoid excessive fluids before collection. For blood tests, fast if instructed (usually 8–12 hours before). Avoid smoking or alcohol for 24 hours before testing if advised.
Reference range
Results are reported as detected, not detected, or variant of uncertain significance (VUS) for each gene analyzed. No numerical reference range applies. Interpretation provided in conjunction with histopathology and clinical findings.N/A
No special patient preparation is required. However, patients should be informed about the genetic nature of the test, potential implications for family members, and may be offered genetic counseling prior to and following testing.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance
Short name
PSA/Urine Prostate Health Panel
Frequently asked questions
Elevated PSA levels in blood or urine can signal prostate issues, including cancer, but they can also be raised in other conditions like infection or benign enlargement. Combined with clinical findings, imaging, and patient history, these results help guide diagnosis and treatment planning.
How long will I need to wait for results?
Can I take anything to lower my PSA levels before the test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy