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Substance concentration of a specific protein in serum/plasma (e.g., related to protein electrophoresis)

Published: August 9, 2026Updated: August 16, 2026

This test measures the distribution of proteins in your blood, helping identify patterns that may indicate conditions like infections, liver disease, or kidney problems.

Quick summary

["Your blood protein profile can reveal hidden health concerns by showing how different proteins separate under an electric field."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
105013-7
Short code
CR-GES11
Synonyms
blaGES-11 Islt/Spm Ql
Category
chemistry
Sample
serum
Container
Sterile, leak-proof container or bacterial culture transport swab; EDTA tube acceptable for blood-derived specimens
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
0–120 years
Method
molgen
CPT
87153
SNOMED
122450003
Specimen volume
1-2 mL for liquid specimens or adequate material on transport swab; minimum 0.5 mL serum
Stability
Room temperature: 24 hours; Refrigerated (2-8°C): 7 days; Frozen (-70°C): 30 days. Transport to laboratory promptly.
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
24–72 hours
Order
routine

This test measures the main protein groups circulating in your blood, including albumin and the globulin fractions known as alpha-1, alpha-2, beta, and gamma globulins. Each of these proteins plays an important role, from maintaining fluid balance and carrying hormones and vitamins to helping your immune system fight infection.

This test typically evaluates the concentration of major protein groups, including albumin, globulins (such as immunoglobulins), and other fractions like alpha, beta, and gamma globulins. These proteins play roles in immunity, blood clotting, and maintaining fluid balance.

Your doctor may order this test to help investigate symptoms such as unexplained fatigue, weight loss, bone pain, swelling, or frequent infections. It is also used to help diagnose or monitor conditions like multiple myeloma, liver or kidney disease, malnutrition, chronic inflammation, and certain immune system disorders.

Healthcare providers may order this test to diagnose or monitor conditions like multiple myeloma, liver disease (e.g., cirrhosis), kidney disease, or chronic infections. It can also help assess nutritional status or detect abnormal protein production.

A small blood sample is drawn from a vein in your arm, usually on the inside of the elbow, and sent to the laboratory for analysis. Fasting is generally not required, but tell your doctor about all medications and supplements you take, because some drugs can influence protein levels. Stay well hydrated and mention any recent illness before the draw.

A blood sample is drawn from a vein, usually in your arm. The blood is then separated into serum (after clotting) or plasma (if anticoagulant is used) for testing. This process helps isolate the proteins for analysis.

Your results are reported as the amount and percentage of each protein fraction and compared with standard reference ranges. A fraction that is unusually high or low can suggest inflammation, liver or kidney problems, nutritional deficiencies, or abnormal protein production. Your doctor interprets the overall pattern together with your symptoms, medical history, and other test results.

Results are often presented as a graph or report showing the relative amounts of each protein group. Abnormal patterns (e.g., high or low globulins, unusual spikes) may signal underlying health issues that require further investigation.

Reference range

Negative (blaGES-11 gene not detected)N/A

Specimen: serum

No special patient preparation required. Inform laboratory if patient is on antimicrobial therapy.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Protein Electrophoresis Profile (Serum/Plasma)

Frequently asked questions

High levels of certain globulins (e.g., immunoglobulins) may suggest autoimmune diseases, infections, or overproduction of antibodies. Low albumin could indicate liver disease, malnutrition, or kidney problems. Electrophoresis helps pinpoint these trends for targeted follow-up.
What does it mean when one of my protein fractions is higher or lower than the normal range on this test?
A high concentration of one protein fraction (e.g., gamma globulins) might indicate conditions like multiple myeloma or chronic infections. A low albumin level could signal liver dysfunction, protein loss from the kidneys, or poor nutritional intake. Your doctor will discuss these findings with you.
The frequency depends on your health condition. If you have a known issue (e.g., liver disease), your doctor may recommend regular monitoring. Otherwise, this test is usually ordered as needed for specific symptoms or diagnostic purposes.
Can lifestyle changes affect my protein electrophoresis results?
Yes, diet (e.g., protein intake), hydration, and certain medications can influence protein levels. Avoiding alcohol and maintaining a balanced diet may help stabilize results. Always follow your healthcare provider’s instructions for preparation.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy