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Serum or Plasma Creatinine Concentration (Substance Concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of creatinine, a waste product from muscle metabolism, in your blood or plasma. It helps assess how well your kidneys are filtering blood.

Quick summary

["Kidney function is evaluated by checking creatinine levels."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
105020-2
Short code
NDM19
Synonyms
blaNDM-19 Islt/Spm Ql
Category
chemistry
Sample
serum
Container
Sterile, leak-proof container or appropriate transport medium (e.g., Copan ESwab, Amies or Stuart transport medium, or Cary-Blair medium)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
0–120 years
Method
molgen
CPT
87798
SNOMED
415684004
Specimen volume
Minimum 0.5-1 mL of specimen or one swab in transport medium
Stability
Room temperature: 2 hours; Refrigerated (2-8°C): 24-48 hours; Frozen (-70°C or below): longer-term storage for batch testing. Follow specific institutional and transport medium manufacturer guidelines.
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to check for kidney disease, monitor kidney function over time, or evaluate symptoms like swelling, fatigue, or changes in urine output. It’s also used before certain surgeries or treatments that affect kidney health.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast for 8–12 hours before the test if it’s part of a broader kidney function panel. Drink plenty of water the day before to help dilute urine if a urine-based test is involved.

What Happens During the Test?

A blood sample is drawn from a vein in your arm by a healthcare professional. If a urine sample is needed, you’ll collect a midstream urine specimen. The sample is sent to a lab for analysis.

What Are Possible Results?

Results are compared to a general reference range, which can vary by lab. High levels may suggest kidney problems, while very low levels could indicate muscle disorders or other conditions. Your provider will interpret results in the context of your overall health.

Reference range

Negative (blaNDM-19 gene not detected)N/A

Specimen: serum

No special patient preparation required prior to specimen collection. Specimen should ideally be collected prior to administration of antimicrobial therapy when clinically feasible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Creatinine Level

Frequently asked questions

What causes creatinine levels to be high?
High creatinine levels can result from kidney disease, dehydration, severe muscle damage, or conditions that reduce blood flow to the kidneys. Chronic kidney disease, diabetes, or high blood pressure are common causes. If you notice symptoms like swelling, frequent urination, or fatigue, discuss these with your doctor.
What causes creatinine levels to be low?
Low creatinine levels may occur if you have very little muscle mass, certain liver or muscle disorders, or conditions that affect protein metabolism. Rarely, it could indicate overhydration or certain medications. Your provider will review your medical history and other test results to determine the cause.
Can diet affect creatinine levels?
Dietary protein intake can influence creatinine levels, but the effect is usually small. Eating a balanced diet with moderate protein is generally fine. If you have kidney concerns, your doctor may recommend adjustments to protein intake to support kidney health.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy