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C-reactive protein (CRP) concentration, serum/plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of C-reactive protein, a protein produced by the liver in response to inflammation in your body. It helps doctors assess whether inflammation is present.

Quick summary

["CRP helps track inflammation, often used to monitor conditions like infections, autoimmune diseases, or after surgery."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
98065-6
Short code
OXA143
Synonyms
blaOXA-143 Islt/Spm Ql
Category
chemistry
Sample
serum
Container
Sterile transport container or bacterial culture swab transport system; molecular-grade collection device preferred
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
CPT
87153
SNOMED
122450008
Specimen volume
1-2 mL of clinical specimen or bacterial isolate; minimum 0.5 mL acceptable
Stability
Room temperature: 2 hours; Refrigerated (2-8°C): 24-48 hours; Frozen (-70°C or below): extended storage for retrospective testing
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–72 hours
Order
routine

Why CRP Matters in Your Health

CRP isn’t specific to any single condition, but it’s a useful marker for detecting and monitoring inflammation. High levels may signal infections, injuries, or inflammatory diseases like rheumatoid arthritis or lupus. Doctors may order this test to check for early signs of problems or to guide treatment decisions.

When This Test Is Done

Your doctor might recommend a CRP test if you have symptoms like fever, joint pain, or unexplained fatigue. It’s also used before surgeries, during chemotherapy, or to evaluate chronic conditions like heart disease or kidney problems. Sometimes, it’s part of a routine checkup to monitor long-term health.

What to Expect Before the Test

No special preparation is needed, but you may be asked to fast for 8–12 hours before the test if it’s part of a fasting panel. On the day of the test, avoid smoking, strenuous activity, or certain medications (like NSAIDs) that could affect results. Bring a list of medications to your doctor’s office.

What the Results Mean

Results are usually reported in milligrams per liter (mg/L). A normal range isn’t always the same for everyone, so your doctor will compare your results to your own baseline or to what’s typical for your condition. Very high levels may prompt further testing, while low levels might raise questions about hidden inflammation.

Reference range

Negative (blaOXA-143 gene not detected); Result reported as Detected or Not DetectedN/A

Specimen: serum

No special patient preparation required. Specimen should be collected prior to initiation of antimicrobial therapy when possible. Collect from site of suspected infection following standard aseptic technique.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

CRP (Serum/Plasma)

Frequently asked questions

What causes elevated CRP levels?
Elevated CRP can result from infections (like pneumonia or urinary tract infections), injuries, surgeries, or autoimmune diseases. It may also appear in conditions like heart disease, kidney problems, or certain cancers. Your doctor will consider your symptoms, medical history, and other test results to determine the cause.
What if my CRP is high?
If your CRP is high, your doctor may recommend additional tests (like blood cultures, imaging, or other inflammatory markers) to find the cause. Treatment could include antibiotics, anti-inflammatory medications, lifestyle changes, or monitoring for underlying conditions. Follow-up tests may be needed to track progress.
Can CRP levels be affected by diet or exercise?
Yes, diet and exercise can influence CRP levels. Regular physical activity tends to lower CRP, while poor diet, obesity, or smoking may increase it. Avoiding processed foods, reducing salt, and maintaining a healthy weight can help keep CRP in a healthier range.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy