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C-reactive protein (CRP) by nephelometry (serum/plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of C-reactive protein in your blood, a marker often used to check for inflammation or infection.

Quick summary

["CRP helps track inflammation, guiding decisions about treatment or further testing."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
105787-6
Short code
OXA48PCR
Synonyms
blaOXA-48-like Ct Bld Pos Qn NAA+probe
Category
chemistry
Sample
whole-blood
Container
Positive blood culture broth from aerobic or anaerobic blood culture bottles (e.g., BACTEC, BacT/ALERT, VersaTREK bottles)
Units
N/A
Ref low
15
Ref high
40
Fasting
false
Population
adult
Sex
all
Age range
0–120 years
Method
probe-amp-tar
CPT
87798
SNOMED
122450008
Specimen volume
1-2 mL of positive blood culture broth; testing performed directly from flagged-positive culture bottle
Stability
Stable for up to 24 hours at room temperature (15-25°C) and up to 72 hours at 2-8°C from the time of blood culture positivity flag. Avoid repeated freeze-thaw cycles. Transport promptly to laboratory.
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
1–8 hours
Order
routine

Why CRP Matters in Your Health

CRP is produced by your liver in response to inflammation. High levels may signal conditions like infections, autoimmune diseases, or tissue damage. It’s not specific to any single illness but can help doctors assess overall body response to injury or illness.

When This Test Is Ordered

Your doctor may order CRP to monitor chronic conditions (e.g., arthritis, heart disease), evaluate symptoms of infection, or check for signs of inflammation after surgery or injury. It’s sometimes used alongside other tests to guide treatment plans.

What to Expect Before the Test

No special preparation is needed, but you may be asked to fast for 8–12 hours before the blood draw if instructed by your provider. Wear comfortable clothing and plan to rest afterward.

What the Results Mean

Results are interpreted based on your health history and symptoms. Very high levels may prompt further testing, while low levels don’t always mean no inflammation is present. Your doctor will discuss findings with you.

Reference range

Negative for blaOXA-48-like carbapenem resistance gene. Ct (cycle threshold) values are reported as semi-quantitative measurements when positive; lower Ct values indicate higher bacterial load. Typical Ct values range from 15-40 cycles.N/A

Specimen: whole-blood

No special patient preparation required. Sample should be collected prior to antimicrobial therapy initiation whenever possible to maximize detection sensitivity. Blood culture bottles should be collected using standard aseptic technique.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: CRP’s Role in Diagnosis and Management

Short name

CRP (Nephelometry)

Frequently asked questions

How often will I need this test?
Your doctor will determine the frequency based on your condition. For example, CRP may be checked monthly for certain chronic illnesses or after an acute event like surgery or trauma.
Can lifestyle changes affect CRP levels?
Yes. Reducing inflammation through diet (e.g., anti-inflammatory foods), exercise, stress management, or medications can lower CRP levels. Avoiding smoking and maintaining a healthy weight may also help.
What if my CRP is elevated?
If elevated, your doctor may recommend additional tests (e.g., blood cultures, imaging) or adjust treatments (e.g., anti-inflammatory medications). Follow-up visits will guide next steps based on your specific situation.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy